Delirium symptoms duration and mortality in SARS-COV2 elderly: results of a multicenter retrospective cohort study.
Aging Clin Exp Res
; 33(8): 2327-2333, 2021 Aug.
Article
in English
| MEDLINE | ID: covidwho-1491489
ABSTRACT
BACKGROUND:
Since the occurrence of the SARS-COV2 pandemic, there has been an increasing interest in investigating the epidemiology of delirium. Delirium is frequent in SARS-COV2 patients and it is associated with increased mortality; however, no information is available on the association between delirium duration in SARS-COV2 patients and related outcomes.AIMS:
The aim of this study is to investigate the association between the duration of delirium symptoms and in-hospital mortality in older patients with SARS-COV2 infection.METHODS:
Retrospective cohort study of patients 65 years of age and older with SARS-CoV 2 infection admitted to two acute geriatric wards and one rehabilitation ward. Delirium symptoms duration was assessed retrospectively with a chart-based validated method. In-hospital mortality was ascertained via medical records.RESULTS:
A total of 241 patients were included. The prevalence of delirium on admission was 16%. The median number of days with delirium symptoms was 4 (IQR 2-6.5) vs. 0 (IQR 0-2) in patients with and without delirium on admission. In the multivariable Cox regression model, each day with a delirium symptom in a patient with the same length of stay was associated with a 10% increase in in-hospital mortality (Hazard ratio 1.1, 95% Confidence interval 1.01-1.2; p = 0.03). Other variables associated with increased risk of in-hospital death were age, comorbidity, CPAP, CRP levels and total number of drugs on admission.CONCLUSIONS:
The study supports the necessity to establish protocols for the monitoring and management of delirium during emergency conditions to allow an appropriate care for older patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Delirium
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Aged
/
Humans
Language:
English
Journal:
Aging Clin Exp Res
Journal subject:
Geriatrics
Year:
2021
Document Type:
Article
Affiliation country:
S40520-021-01899-8
Similar
MEDLINE
...
LILACS
LIS