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Liquid repellency enabled antipathogen coatings.
Li, W; Wang, Y; Tang, X; Yuen, T T T; Han, X; Li, J; Huang, N; Chan, J F W; Chu, H; Wang, L.
  • Li W; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong.
  • Wang Y; HKU-Zhejiang Institute of Research and Innovation (HKU-ZIRI), Hangzhou, Zhejiang 311300, China.
  • Tang X; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong.
  • Yuen TTT; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong.
  • Han X; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
  • Li J; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong.
  • Huang N; HKU-Zhejiang Institute of Research and Innovation (HKU-ZIRI), Hangzhou, Zhejiang 311300, China.
  • Chan JFW; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong.
  • Chu H; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong.
  • Wang L; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Mater Today Bio ; 12: 100145, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1492443
ABSTRACT
Currently, Coronavirus Disease 2019 (COVID-19)-a respiratory contagion spreading through expiratory droplets-has evolved into a global pandemic, severely impacting the public health. Importantly, the emerging of immune evasion SARS-CoV-2 variants and the limited effect of current antivirals against SARS-CoV-2 in clinical trials suggested that alternative strategies in addition to the conventional vaccines and antivirals are required to successfully control the COVID-19 pandemic. Here, we propose to use liquid-repellent coatings to prevent the spread of the disease in the absence of effective vaccines, antimicrobial agents, or therapeutics, wherein the deposition and penetration of pathogen droplets are prohibited. We use SARS-CoV-2 as a model pathogen and find that SARS-CoV-2 remnants are reduced by seven orders of magnitude on coated surfaces, yielding a repelling efficacy far outperforming the inactivation rate of disinfectants. The SARS-CoV-2 remnant scales exponentially with the liquid/solid adhesion, uncovering the mechanism and effective means for minimizing pathogen attachment. The antipathogen coating that both repels and inactivates pathogens is demonstrated by incorporating the super-liquid-repellent coating with antipathogen additives. Together with its versatility over a wide range of substrates and pathogens, the novel antipathogen coating is of considerable value for infection control in everyday life as well as during pandemics.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Journal: Mater Today Bio Year: 2021 Document Type: Article Affiliation country: J.mtbio.2021.100145

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Journal: Mater Today Bio Year: 2021 Document Type: Article Affiliation country: J.mtbio.2021.100145