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Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen.
Dobaño, Carlota; Jiménez, Alfons; Rubio, Rocío; Alonso, Selena; Ramírez-Morros, Anna; Vidal, Marta; Vidal-Alaball, Josep; Ruiz-Comellas, Anna; García-Basteiro, Alberto L; Izquierdo, Luis; Aguilar, Ruth; Moncunill, Gemma.
  • Dobaño C; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain; CIBER de Enfermedades Infecciosas, Madrid, Spain. Electronic address: carlota.dobano@isglobal.org.
  • Jiménez A; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Rubio R; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain.
  • Alonso S; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain.
  • Ramírez-Morros A; Unitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Sant Fruitós de Bages, Spain.
  • Vidal M; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain.
  • Vidal-Alaball J; Unitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Sant Fruitós de Bages, Spain; Health Promotion in Rural Areas Research Group, Gerència Territorial de la Catalunya Central, Institut Català de la S
  • Ruiz-Comellas A; Unitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Sant Fruitós de Bages, Spain; Health Promotion in Rural Areas Research Group, Gerència Territorial de la Catalunya Central, Institut Català de la S
  • García-Basteiro AL; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain; CIBER de Enfermedades Infecciosas, Madrid, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
  • Izquierdo L; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain; CIBER de Enfermedades Infecciosas, Madrid, Spain.
  • Aguilar R; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain.
  • Moncunill G; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain; CIBER de Enfermedades Infecciosas, Madrid, Spain.
Transl Res ; 240: 26-32, 2022 02.
Article in English | MEDLINE | ID: covidwho-1492708
ABSTRACT
Antibodies to the nucleocapsid (N) antigen are suggested to be used to monitor infections after COVID-19 vaccination, as first generation subunit vaccines are based on the spike (S) protein. We used multiplex immunoassays to simultaneously measure antibody responses to different fragments of the SARS-CoV-2 S and N antigens for evaluating the immunogenicity of the mRNA-1273 (Spykevax) and the BNT162b2 (Comirnaty) vaccines in 445 health care workers. We report a >4-fold increase post-vaccination of IgG levels to the full length (N FL) and C-terminus of N (N CT) in 5.2% and 18.0% of individuals, respectively, and of IgA in 3.6% (N FL) and 9.0% (N CT) of them. The increase in IgG levels and avidity was more pronounced after Spykevax than Comirnaty vaccination (36.2% vs 13.1% for N CT, and 10.6% vs 3.7% for N FL). Data suggest the induction of cross-reactive antibodies against the N CT region after administering these S-based vaccines, and this should be taken into account when using N seropositivity to detect breakthroughs.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Nucleocapsid / Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: Transl Res Journal subject: Medicine / Laboratory Techniques and procedures Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nucleocapsid / Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: Transl Res Journal subject: Medicine / Laboratory Techniques and procedures Year: 2022 Document Type: Article