Your browser doesn't support javascript.
BNT162b2 mRNA vaccine elicited antibody response in blood and milk of breastfeeding women.
Rosenberg-Friedman, Michal; Kigel, Aya; Bahar, Yael; Werbner, Michal; Alter, Joel; Yogev, Yariv; Dror, Yael; Lubetzky, Ronit; Dessau, Moshe; Gal-Tanamy, Meital; Many, Ariel; Wine, Yariv.
  • Rosenberg-Friedman M; Department of Obstetrics and Gynecology, Lis Maternity & Women's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
  • Kigel A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Bahar Y; The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Werbner M; The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Alter J; Molecular Virology Lab, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
  • Yogev Y; The Laboratory of Structural Biology of Infectious Diseases, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
  • Dror Y; Department of Obstetrics and Gynecology, Lis Maternity & Women's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
  • Lubetzky R; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Dessau M; The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Gal-Tanamy M; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Many A; Department of Pediatrics, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
  • Wine Y; The Laboratory of Structural Biology of Infectious Diseases, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Nat Commun ; 12(1): 6222, 2021 10 28.
Article in English | MEDLINE | ID: covidwho-1493103
ABSTRACT
The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and infection-related infant mortality. However, data regarding the induction and dynamics of breastmilk antibodies following administration of the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine is scarce, as pregnant and lactating women were not included in the initial vaccine clinical trials. Here, we investigate the dynamics of the vaccine-specific antibody response in breastmilk and serum in a prospective cohort of ten lactating women who received two doses of the mRNA vaccine. We show that the antibody response is rapid and highly synchronized between breastmilk and serum, reaching stabilization 14 days after the second dose. The response in breastmilk includes both IgG and IgA with neutralization capacity.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Breast Feeding / RNA, Messenger / COVID-19 Vaccines Limits: Adult / Animals / Female / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-26507-1

Full text: Available Collection: International databases Database: MEDLINE Main subject: Breast Feeding / RNA, Messenger / COVID-19 Vaccines Limits: Adult / Animals / Female / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-26507-1