Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19.
Redox Rep
; 26(1): 184-189, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1493448
ABSTRACT
BACKGROUND:
COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels, oxidative stress markers and disease severity in hospitalized COVID-19 patients.METHODS:
Vitamin D levels were measured in 33 patients with COVID-19. The total antioxidant power and plasma peroxides were determined in serum.RESULTS:
Severe COVID-19 patients have lower vitamin D levels (18.39 ± 2.29â ng/mL vs. 28.47 ± 3.05â ng/mL, p < .05) and higher oxidative stress compared to the moderate group. When divided according to serum vitamin D levels, significantly higher values of LDH (604.8 ± 76.98 IU/mL vs. 261.57 ± 47.33 IU/mL) and D-dimer (5978 ± 2028ng/mL vs. 977.7 ± 172â ng/mL) were obtained in the group with vitamin D below 30â ng/mL, followed with significantly higher levels of plasma peroxides (d-ROMs 414.9 ± 15.82 U.Carr vs. 352.4 ± 18.77 U.Carr; p < .05) and oxidative stress index (OSI 92.25 ± 6.60 vs. 51.89 ± 6.45; p < .001).CONCLUSION:
The presented data provide a justification to consider vitamin D as an important factor that could ameliorate disease severity through its anti-inflammatory and antioxidant effects.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vitamin D
/
Oxidative Stress
/
COVID-19
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
English
Journal:
Redox Rep
Journal subject:
Biochemistry
/
Metabolism
Year:
2021
Document Type:
Article
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