Could COVID-19 induce remission of acute leukemia?
Hematology
; 26(1): 870-873, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1493499
ABSTRACT
BACKGROUND:
COVID-19 viral pandemic caused many mortalities in cancer patients especially those with hematological malignancies. The immunological response to COVID-19 infection is responsible for the outcome of cases whether mild, severe or critical. CASE PRESENTATION Two cases presented with moderate COVID-19 viral infection, concomitant with acute myeloid leukemia and T acute lymphoblastic leukemia, respectively. Surprisingly, after the administration of COVID-19 supportive therapy, the cases showed disease remission after a follow-up period of 12 and 5 months, respectively. Additionally, the blast cells dropped to only 3% and 0% in the bone marrow aspirates of those two cases, respectively, after it was 30% in both cases at diagnosis.CONCLUSION:
The immune response that emerged against COVID-19 infection could potentially produce anti-tumor immunity in some patients, or the virus may act as an oncolytic virus. However, further investigations are required to explain this phenomenon, which may help in finding a possible new targeted therapy for these cases.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Leukemia, Myeloid, Acute
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
COVID-19
Type of study:
Case report
/
Cohort study
/
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Hematology
Journal subject:
Hematology
Year:
2021
Document Type:
Article
Affiliation country:
16078454.2021.1992117
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