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UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates.
Rosenke, Kyle; Feldmann, Friederike; Okumura, Atsushi; Hansen, Frederick; Tang-Huau, Tsing-Lee; Meade-White, Kimberly; Kaza, Benjamin; Callison, Julie; Lewis, Matthew C; Smith, Brian J; Hanley, Patrick W; Lovaglio, Jamie; Jarvis, Michael A; Shaia, Carl; Feldmann, Heinz.
  • Rosenke K; Laboratory of Virology, Hamilton, MT, USA.
  • Feldmann F; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
  • Okumura A; Laboratory of Virology, Hamilton, MT, USA.
  • Hansen F; Laboratory of Virology, Hamilton, MT, USA.
  • Tang-Huau TL; Laboratory of Virology, Hamilton, MT, USA.
  • Meade-White K; Laboratory of Virology, Hamilton, MT, USA.
  • Kaza B; Laboratory of Virology, Hamilton, MT, USA.
  • Callison J; Laboratory of Virology, Hamilton, MT, USA.
  • Lewis MC; Laboratory of Virology, Hamilton, MT, USA.
  • Smith BJ; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
  • Hanley PW; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
  • Lovaglio J; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
  • Jarvis MA; Laboratory of Virology, Hamilton, MT, USA.
  • Shaia C; University of Plymouth, Plymouth, UK.
  • Feldmann H; The Vaccine Group Ltd, Plymouth, UK.
Emerg Microbes Infect ; 10(1): 2173-2182, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1493581
ABSTRACT
The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, we compared African green monkeys infected intranasally with either the UK B.1.1.7 (Alpha) variant or its contemporary D614G progenitor. Both variants caused mild respiratory disease with no significant differences in clinical presentation. Significantly higher levels of viral RNA and infectious virus were found in upper and lower respiratory tract samples and tissues from B.1.1.7 infected animals. Interestingly, D614G infected animals showed significantly higher levels of viral RNA and infectious virus in rectal swabs and gastrointestinal tissues. Our results indicate that B.1.1.7 infection in African green monkeys is associated with increased respiratory replication and shedding but no disease enhancement similar to human B.1.1.7 cases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory System / Virus Replication / Chlorocebus aethiops / Virus Shedding / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Variants Limits: Animals Country/Region as subject: Europa Language: English Journal: Emerg Microbes Infect Year: 2021 Document Type: Article Affiliation country: 22221751.2021.1997074

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory System / Virus Replication / Chlorocebus aethiops / Virus Shedding / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Variants Limits: Animals Country/Region as subject: Europa Language: English Journal: Emerg Microbes Infect Year: 2021 Document Type: Article Affiliation country: 22221751.2021.1997074