UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates.
Emerg Microbes Infect
; 10(1): 2173-2182, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1493581
ABSTRACT
The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, we compared African green monkeys infected intranasally with either the UK B.1.1.7 (Alpha) variant or its contemporary D614G progenitor. Both variants caused mild respiratory disease with no significant differences in clinical presentation. Significantly higher levels of viral RNA and infectious virus were found in upper and lower respiratory tract samples and tissues from B.1.1.7 infected animals. Interestingly, D614G infected animals showed significantly higher levels of viral RNA and infectious virus in rectal swabs and gastrointestinal tissues. Our results indicate that B.1.1.7 infection in African green monkeys is associated with increased respiratory replication and shedding but no disease enhancement similar to human B.1.1.7 cases.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory System
/
Virus Replication
/
Chlorocebus aethiops
/
Virus Shedding
/
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Variants
Limits:
Animals
Country/Region as subject:
Europa
Language:
English
Journal:
Emerg Microbes Infect
Year:
2021
Document Type:
Article
Affiliation country:
22221751.2021.1997074
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