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Germinal Center-Induced Immunity Is Correlated With Protection Against SARS-CoV-2 Reinfection But Not Lung Damage.
Kim, Green; Kim, Dong Ho; Oh, Hanseul; Bae, Seongman; Kwon, Jisoo; Kim, Min-Jae; Lee, Eunyoung; Hwang, Eun-Ha; Jung, Hoyin; Koo, Bon-Sang; Baek, Seung Ho; Kang, Philyong; An, You Jung; Park, Jae-Hak; Park, Jong-Hwan; Lyoo, Kwang-Soo; Ryu, Choong-Min; Kim, Sung-Han; Hong, Jung Joo.
  • Kim G; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Kim DH; Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, South Jeolla, Republic of Korea.
  • Oh H; Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Republic of Korea.
  • Bae S; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Kwon J; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Kim MJ; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Lee E; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Hwang EH; Division of Infectious Diseases, Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Republic of Korea.
  • Jung H; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Koo BS; Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, South Jeolla, Republic of Korea.
  • Baek SH; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Kang P; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • An YJ; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Park JH; Futuristic Animal Resource Centre, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Park JH; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.
  • Lyoo KS; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
  • Ryu CM; Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, South Jeolla, Republic of Korea.
  • Kim SH; Korea Zoonosis Research Institute, Chonbuk National University, Iksan, Republic of Korea.
  • Hong JJ; Infectious Disease Research Centre, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
J Infect Dis ; 224(11): 1861-1872, 2021 12 01.
Article in English | MEDLINE | ID: covidwho-1493829
ABSTRACT
Germinal centers (GCs) elicit protective humoral immunity through a combination of antibody-secreting cells and memory B cells, following pathogen invasion or vaccination. However, the possibility of a GC response inducing protective immunity against reinfection following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. We found GC activity was consistent with seroconversion observed in recovered macaques and humans. Rechallenge with a different clade of virus resulted in significant reduction in replicating virus titers in respiratory tracts in macaques with high GC activity. However, diffuse alveolar damage and increased fibrotic tissue were observed in lungs of reinfected macaques. Our study highlights the importance of GCs developed during natural SARS-CoV-2 infection in managing viral loads in subsequent infections. However, their ability to alleviate lung damage remains to be determined. These results may improve understanding of SARS-CoV-2-induced immune responses, resulting in better coronavirus disease 2019 (COVID-19) diagnosis, treatment, and vaccine development.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Germinal Center / Immunity, Humoral / Reinfection / COVID-19 Topics: Vaccines Limits: Animals / Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Germinal Center / Immunity, Humoral / Reinfection / COVID-19 Topics: Vaccines Limits: Animals / Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article