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Entry, egress and vertical transmission of SARS-CoV-2.
Zhang, Hui; Zhang, Hong.
  • Zhang H; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Zhang H; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
J Mol Cell Biol ; 13(3): 168-174, 2021 07 06.
Article in English | MEDLINE | ID: covidwho-2288493
ABSTRACT
The high infectivity and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused the COVID-19 outbreak, one of the most devastating pandemics in more than a century. This pandemic has already left a trail of destruction, including enormous loss of life, a global economic slump, and widespread psychological damage. Despite assiduous world-wide endeavors, an effective cure for COVID-19 is still lacking. Surprisingly, infected neonates and children have relatively mild clinical manifestations and a much lower fatality rate than elderly adults. Recent studies have unambiguously demonstrated the vertical transmission of SARS-CoV-2 from infected pregnant women to fetuses, which creates yet another challenge for disease prevention. In this review, we will summarize the molecular mechanism for entry of SARS-CoV-2 into host cells, the basis for the failure of the lungs and other organs in severe acute cases, and the evidence for congenital transmission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Infectious Disease Transmission, Vertical / Virus Internalization / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Female / Humans / Pregnancy Language: English Journal: J Mol Cell Biol Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: Jmcb

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Infectious Disease Transmission, Vertical / Virus Internalization / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Female / Humans / Pregnancy Language: English Journal: J Mol Cell Biol Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: Jmcb