Entry, egress and vertical transmission of SARS-CoV-2.
J Mol Cell Biol
; 13(3): 168-174, 2021 07 06.
Article
in English
| MEDLINE | ID: covidwho-2288493
ABSTRACT
The high infectivity and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused the COVID-19 outbreak, one of the most devastating pandemics in more than a century. This pandemic has already left a trail of destruction, including enormous loss of life, a global economic slump, and widespread psychological damage. Despite assiduous world-wide endeavors, an effective cure for COVID-19 is still lacking. Surprisingly, infected neonates and children have relatively mild clinical manifestations and a much lower fatality rate than elderly adults. Recent studies have unambiguously demonstrated the vertical transmission of SARS-CoV-2 from infected pregnant women to fetuses, which creates yet another challenge for disease prevention. In this review, we will summarize the molecular mechanism for entry of SARS-CoV-2 into host cells, the basis for the failure of the lungs and other organs in severe acute cases, and the evidence for congenital transmission.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Infectious Disease Transmission, Vertical
/
Virus Internalization
/
SARS-CoV-2
/
COVID-19
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
J Mol Cell Biol
Journal subject:
Molecular Biology
Year:
2021
Document Type:
Article
Affiliation country:
Jmcb
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