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Complete protection by a single-dose skin patch-delivered SARS-CoV-2 spike vaccine.
McMillan, Christopher L D; Choo, Jovin J Y; Idris, Adi; Supramaniam, Aroon; Modhiran, Naphak; Amarilla, Alberto A; Isaacs, Ariel; Cheung, Stacey T M; Liang, Benjamin; Bielefeldt-Ohmann, Helle; Azuar, Armira; Acharya, Dhruba; Kelly, Gabrielle; Fernando, Germain J P; Landsberg, Michael J; Khromykh, Alexander A; Watterson, Daniel; Young, Paul R; McMillan, Nigel A J; Muller, David A.
  • McMillan CLD; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Choo JJY; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Idris A; Menzies Health Institute Queensland, School of Pharmacy, Anatomy and Medical Sciences, Griffith University, Gold Coast, Queensland 4222, Australia.
  • Supramaniam A; Menzies Health Institute Queensland, School of Pharmacy, Anatomy and Medical Sciences, Griffith University, Gold Coast, Queensland 4222, Australia.
  • Modhiran N; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Amarilla AA; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Isaacs A; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Cheung STM; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Liang B; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Bielefeldt-Ohmann H; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Azuar A; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland 4072 and 4029, Australia.
  • Acharya D; School of Veterinary Science, University of Queensland Gatton Campus, Gatton, Queensland 4343, Australia.
  • Kelly G; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Fernando GJP; Menzies Health Institute Queensland, School of Pharmacy, Anatomy and Medical Sciences, Griffith University, Gold Coast, Queensland 4222, Australia.
  • Landsberg MJ; Menzies Health Institute Queensland, School of Pharmacy, Anatomy and Medical Sciences, Griffith University, Gold Coast, Queensland 4222, Australia.
  • Khromykh AA; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  • Watterson D; Vaxxas Pty Ltd, Translational Research Institute, 37 Kent Street, Brisbane, Queensland 4102, Australia.
  • Young PR; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  • McMillan NAJ; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland 4072 and 4029, Australia.
  • Muller DA; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
Sci Adv ; 7(44): eabj8065, 2021 Oct 29.
Article in English | MEDLINE | ID: covidwho-1494911
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 160 million people and resulted in more than 3.3 million deaths, and despite the availability of multiple vaccines, the world still faces many challenges with their rollout. Here, we use the high-density microarray patch (HD-MAP) to deliver a SARS-CoV-2 spike subunit vaccine directly to the skin. We show that the vaccine is thermostable on the patches, with patch delivery enhancing both cellular and antibody immune responses. Elicited antibodies potently neutralize clinically relevant isolates including the Alpha and Beta variants. Last, a single dose of HD-MAP­delivered spike provided complete protection from a lethal virus challenge in an ACE2-transgenic mouse model. Collectively, these data show that HD-MAP delivery of a SARS-CoV-2 vaccine was superior to traditional needle-and-syringe vaccination and may be a significant addition to the ongoing COVID-19 (coronavirus disease 2019) pandemic.

Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Journal: Sci Adv Year: 2021 Document Type: Article Affiliation country: Sciadv.abj8065

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Journal: Sci Adv Year: 2021 Document Type: Article Affiliation country: Sciadv.abj8065