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DNA Mutations via Chern-Simons Currents.
Bajardi, Francesco; Altucci, Lucia; Benedetti, Rosaria; Capozziello, Salvatore; Sorbo, Maria Rosaria Del; Franci, Gianluigi; Altucci, Carlo.
  • Bajardi F; Dipartimento di Fisica "Ettore Pancini", Università degli Studi di Napoli"Federico II", Compl. Univ. di Monte S. Angelo, Edificio G, Via Cinthia, 80126 Napoli, Italy.
  • Altucci L; INFN Sezione di Napoli, Compl. Univ. di Monte S. Angelo, Edificio G, Via Cinthia, 80126 Napoli, Italy.
  • Benedetti R; Dipartimento di Medicina di Precisione, Università degli Studi della Campania "L. Vanvitelli", Napoli, Italy.
  • Capozziello S; Biogem "Istituto di Biologia molecolare e genetica", 83031 Ariano Irpino, Italy.
  • Sorbo MRD; Dipartimento di Medicina di Precisione, Università degli Studi della Campania "L. Vanvitelli", Napoli, Italy.
  • Franci G; Dipartimento di Fisica "Ettore Pancini", Università degli Studi di Napoli"Federico II", Compl. Univ. di Monte S. Angelo, Edificio G, Via Cinthia, 80126 Napoli, Italy.
  • Altucci C; INFN Sezione di Napoli, Compl. Univ. di Monte S. Angelo, Edificio G, Via Cinthia, 80126 Napoli, Italy.
Eur Phys J Plus ; 136(10): 1080, 2021.
Article in English | MEDLINE | ID: covidwho-1495657
Preprint
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ABSTRACT
We test the validity of a possible schematization of DNA structure and dynamics based on the Chern-Simons theory, that is a topological field theory mostly considered in the context of effective gravity theories. By means of the expectation value of the Wilson Loop, derived from this analogue gravity approach, we find the point-like curvature of genomic strings in KRAS human gene and COVID-19 sequences, correlating this curvature with the genetic mutations. The point-like curvature profile, obtained by means of the Chern-Simons currents, can be used to infer the position of the given mutations within the genetic string. Generally, mutations take place in the highest Chern-Simons current gradient locations and subsequent mutated sequences appear to have a smoother curvature than the initial ones, in agreement with a free energy minimization argument.

Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Eur Phys J Plus Year: 2021 Document Type: Article Affiliation country: Epjp

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Eur Phys J Plus Year: 2021 Document Type: Article Affiliation country: Epjp