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Diffusion capacity abnormalities for carbon monoxide in patients with COVID-19 at 3-month follow-up.
Qin, Wei; Chen, Shi; Zhang, Yunxia; Dong, Fen; Zhang, Zhu; Hu, Bingzhu; Zhu, Ziyang; Li, Fajiu; Wang, Xiaojiang; Wang, Yimin; Zhen, Kaiyuan; Wang, Jing; Wan, YuLei; Li, Hongbo; Elalamy, Ismaïl; Li, Chenghong; Zhai, Zhenguo; Wang, Chen.
  • Qin W; Dept of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China.
  • Chen S; These authors contributed equally as co-first authors.
  • Zhang Y; Dept of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China.
  • Dong F; These authors contributed equally as co-first authors.
  • Zhang Z; Dept of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Hu B; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Zhu Z; National Clinical Research Center for Respiratory Diseases, Beijing, China.
  • Li F; These authors contributed equally as co-first authors.
  • Wang X; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
  • Wang Y; These authors contributed equally as co-first authors.
  • Zhen K; Dept of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Wang J; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Wan Y; National Clinical Research Center for Respiratory Diseases, Beijing, China.
  • Li H; These authors contributed equally as co-first authors.
  • Elalamy I; Dept of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China.
  • Li C; Dept of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China.
  • Zhai Z; Dept of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China.
  • Wang C; Dept of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China.
Eur Respir J ; 58(1)2021 07.
Article in English | MEDLINE | ID: covidwho-1496128
ABSTRACT

OBJECTIVE:

To evaluate pulmonary function and clinical symptoms in coronavirus disease 2019 (COVID-19) survivors within 3 months after hospital discharge, and to identify risk factors associated with impaired lung function. METHODS AND

MATERIAL:

COVID-19 patients were prospectively followed-up with pulmonary function tests and clinical characteristics for 3 months following discharge from a hospital in Wuhan, China between January and February 2020.

RESULTS:

647 patients were included. 87 (13%) patients presented with weakness, 63 (10%) with palpitations and 56 (9%) with dyspnoea. The prevalence of each of the three symptoms were markedly higher in severe patients than nonsevere patients (19% versus 10% for weakness, p=0.003; 14% versus 7% for palpitations, p=0.007; 12% versus 7% for dyspnoea, p=0.014). Results of multivariable regression showed increased odds of ongoing symptoms among severe patients (OR 1.7, 95% CI 1.1-2.6; p=0.026) or patients with longer hospital stays (OR 1.03, 95% CI 1.00-1.05; p=0.041). Pulmonary function test results were available for 81 patients, including 41 nonsevere and 40 severe patients. In this subgroup, 44 (54%) patients manifested abnormal diffusing capacity of the lung for carbon monoxide (D LCO) (68% severe versus 42% nonsevere patients, p=0.019). Chest computed tomography (CT) total severity score >10.5 (OR 10.4, 95% CI 2.5-44.1; p=0.001) on admission and acute respiratory distress syndrome (ARDS) (OR 4.6, 95% CI 1.4-15.5; p=0.014) were significantly associated with impaired D LCO. Pulmonary interstitial damage may be associated with abnormal D LCO.

CONCLUSION:

Pulmonary function, particularly D LCO, declined in COVID-19 survivors. This decrease was associated with total severity score of chest CT >10.5 and ARDS occurrence. Pulmonary interstitial damage might contribute to the imparied D LCO.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Carbon Monoxide / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Country/Region as subject: Asia Language: English Year: 2021 Document Type: Article Affiliation country: 13993003.03677-2020

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Carbon Monoxide / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Country/Region as subject: Asia Language: English Year: 2021 Document Type: Article Affiliation country: 13993003.03677-2020