Diffusion capacity abnormalities for carbon monoxide in patients with COVID-19 at 3-month follow-up.
Eur Respir J
; 58(1)2021 07.
Article
in English
| MEDLINE | ID: covidwho-1496128
ABSTRACT
OBJECTIVE:
To evaluate pulmonary function and clinical symptoms in coronavirus disease 2019 (COVID-19) survivors within 3â months after hospital discharge, and to identify risk factors associated with impaired lung function. METHODS ANDMATERIAL:
COVID-19 patients were prospectively followed-up with pulmonary function tests and clinical characteristics for 3â months following discharge from a hospital in Wuhan, China between January and February 2020.RESULTS:
647 patients were included. 87 (13%) patients presented with weakness, 63 (10%) with palpitations and 56 (9%) with dyspnoea. The prevalence of each of the three symptoms were markedly higher in severe patients than nonsevere patients (19% versus 10% for weakness, p=0.003; 14% versus 7% for palpitations, p=0.007; 12% versus 7% for dyspnoea, p=0.014). Results of multivariable regression showed increased odds of ongoing symptoms among severe patients (OR 1.7, 95% CI 1.1-2.6; p=0.026) or patients with longer hospital stays (OR 1.03, 95% CI 1.00-1.05; p=0.041). Pulmonary function test results were available for 81 patients, including 41 nonsevere and 40 severe patients. In this subgroup, 44 (54%) patients manifested abnormal diffusing capacity of the lung for carbon monoxide (D LCO) (68% severe versus 42% nonsevere patients, p=0.019). Chest computed tomography (CT) total severity score >10.5 (OR 10.4, 95% CI 2.5-44.1; p=0.001) on admission and acute respiratory distress syndrome (ARDS) (OR 4.6, 95% CI 1.4-15.5; p=0.014) were significantly associated with impaired D LCO. Pulmonary interstitial damage may be associated with abnormal D LCO.CONCLUSION:
Pulmonary function, particularly D LCO, declined in COVID-19 survivors. This decrease was associated with total severity score of chest CT >10.5 and ARDS occurrence. Pulmonary interstitial damage might contribute to the imparied D LCO.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Carbon Monoxide
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
13993003.03677-2020
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