Molecular mimicry of NMDA receptors may contribute to neuropsychiatric symptoms in severe COVID-19 cases.
J Neuroinflammation
; 18(1): 245, 2021 Oct 28.
Article
in English
| MEDLINE | ID: covidwho-1496192
ABSTRACT
Approximately 30% of individuals with severe SARS-CoV-2 infections also develop neurological and psychiatric complaints. In rare cases, the occurrence of autoimmune encephalitis has been reported after SARS-CoV-2 infection. In this systematic review, we have identified eight SARS-CoV-2-associated cases of anti-NMDA receptor encephalitis. All had cerebrospinal fluid antibodies against the NMDA receptor and a recent onset of working memory deficits, altered mental status, or psychiatric symptoms, such as confusion, agitation, auditory hallucination, catatonia and speech dysfunction. All patients received high-dose steroid and immunoglobulin therapeutics and conditions improved in each case. These findings suggest that clinical attention should be paid to warning signs of autoimmune encephalitis in severe COVID-19 cases. If characteristic features of autoimmune encephalitis are present, autoantibody diagnostics should be performed and confirmed cases should be treated with immunotherapy to minimize neurological impairments.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Receptors, N-Methyl-D-Aspartate
/
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
/
COVID-19
/
Mental Disorders
Type of study:
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
/
Young adult
Language:
English
Journal:
J Neuroinflammation
Journal subject:
Neurology
Year:
2021
Document Type:
Article
Affiliation country:
S12974-021-02293-x
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