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Heart-rate-variability (HRV), predicts outcomes in COVID-19.
Mol, Maartje B A; Strous, Maud T A; van Osch, Frits H M; Vogelaar, F Jeroen; Barten, Dennis G; Farchi, Moshe; Foudraine, Norbert A; Gidron, Yori.
  • Mol MBA; Department of Surgery, VieCuri Medical Centre Venlo, Venlo, The Netherlands.
  • Strous MTA; Department of Surgery, VieCuri Medical Centre Venlo, Venlo, The Netherlands.
  • van Osch FHM; Department of Intensive Care, VieCuri Medical Centre Venlo, Venlo, The Netherlands.
  • Vogelaar FJ; Department of Epidemiology, VieCuri Medical Centre Venlo, Venlo, The Netherlands.
  • Barten DG; Department of Surgery, VieCuri Medical Centre Venlo, Venlo, The Netherlands.
  • Farchi M; Department of Emergency Medicine, VieCuri Medical Centre Venlo, Venlo, The Netherlands.
  • Foudraine NA; School of Social Work, Tel-Hai College, Qiryat Shemona, Israël.
  • Gidron Y; Department of Intensive Care, VieCuri Medical Centre Venlo, Venlo, The Netherlands.
PLoS One ; 16(10): e0258841, 2021.
Article in English | MEDLINE | ID: covidwho-1496516
ABSTRACT

BACKGROUND:

Patients with COVID-19 present with a variety of clinical manifestations, ranging from mild or asymptomatic disease to severe illness and death. Whilst previous studies have clarified these and several other aspects of COVID-19, one of the ongoing challenges regarding COVID-19 is to determine which patients are at risk of adverse outcomes of COVID-19 infection. It is hypothesized that this is the result of insufficient inhibition of the immune response, with the vagus nerve being an important neuro-immuno-modulator of inflammation. Vagus nerve activity can be non-invasively indexed by heart-rate-variability (HRV). Therefore, we aimed to assess the prognostic value of HRV, as a surrogate marker for vagus nerve activity, in predicting mortality and intensive care unit (ICU) referral, in patients hospitalized with COVID-19.

METHODS:

A retrospective cohort study including all consecutive patients (n = 271) diagnosed and hospitalized with COVID-19 between March 2020 and May 2020, without a history of cardiac arrhythmias (including atrial and ventricular premature contractions), pacemaker, or current bradycardia (heart rate <50 bpm) or tachycardia (heart rate >110 bpm). HRV was based on one 10s ECG recorded at admission. 3-week survival and ICU referral were examined.

RESULTS:

HRV indexed as standard deviation of normal to normal heartbeat intervals (SDNN) predicted survival (H.R. = 0.53 95%CI 0.31-0.92). This protective role was observed only in patients aged 70 years and older, not in younger patients. HRV below median value also predicted ICU referral within the first week of hospitalization (H.R = 0.51, 95%CI 0.29-0.90, P = 0.021).

CONCLUSION:

Higher HRV predicts greater chances of survival, especially in patients aged 70 years and older with COVID-19, independent of major prognostic factors. Low HRV predicts ICU indication and admission in the first week after hospitalization.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Rate Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0258841

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Rate Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0258841