The Role of Endothelial Related Circulating Biomarkers in COVID-19. A Systematic Review and Meta-analysis.
Curr Med Chem
; 29(21): 3790-3805, 2022.
Article
in English
| MEDLINE | ID: covidwho-1496773
ABSTRACT
BACKGROUND:
Several studies have revealed the link between Coronavirus Disease 2019 (COVID-19) and endothelial dysfunction. To better understand the global pattern of this relationship, we conducted a meta-analysis on endothelial biomarkers related to COVID-19 severity.METHODS:
We systematically searched the literature up to March 10, 2021, for studies investigating the association between COVID-19 severity and the following endothelial biomarkers Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), E-selectin, P-selectin, Von Willebrand Factor Antigen (VWFAg), soluble Thrombomodulin (sTM), Mid-regional pro-adrenomedullin (MR-proADM), and Angiopoietin-2 (Ang-2). Pooled estimates and mean differences (PMD) for each biomarker were reported.RESULTS:
A total of 27 studies (n=2213 patients) were included. Critically ill patients presented with higher levels of MR-proADM (PMD 0.71 nmol/L, 95% CI 0.22 to 1.20 nmol/L, p=0.02), E-selectin (PMD 13,32 pg/ml, 95% CI 4,89 to 21,75 pg/ml, p=0.008), VCAM-1 (PMD 479 ng/ml, 95% CI 64 to 896 ng/ml, p=0.03), VWF-Ag (PMD 110.5 IU/dl, 95% CI 44.8 to 176.1 IU/dl, p=0.04) and Ang-2 (PMD 2388 pg/ml, 95% CI 1121 to 3655 pg/ml, p=0.003), as compared to non-critically ill ones. ICAM-1, P-selectin and thrombomodulin did not differ between the two groups (p>0.05).CONCLUSION:
Endothelial biomarkers display significant heterogeneity in COVID-19 patients, with higher MR-proADM, E-selectin, VCAM-1, VWF-Ag, and Ang-2 levels being associated with increased severity. These findings strengthen the evidence on the key role of endothelial dysfunction in disease progress.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vascular Diseases
/
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Curr Med Chem
Journal subject:
Chemistry
Year:
2022
Document Type:
Article
Affiliation country:
0929867328666211026124033
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