Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2-Associated Deaths.

Heinrich, Fabian; Schröder, Ann Sophie; Gerberding, Anna-Lina; Gerling, Moritz; Langenwalder, Felicia; Lange, Philine; Heinemann, Axel; Bibiza-Freiwald, Eric; Nörz, Dominik Sebastian; Aepfelbacher, Martin; Pfefferle, Susanne; Ondruschka, Benjamin; Lütgehetmann, Marc

Heinrich, Fabian; Schröder, Ann Sophie; Gerberding, Anna-Lina; Gerling, Moritz; Langenwalder, Felicia; Lange, Philine; Heinemann, Axel; Bibiza-Freiwald, Eric; Nörz, Dominik Sebastian; Aepfelbacher, Martin; Pfefferle, Susanne; Ondruschka, Benjamin; Lütgehetmann, Marc.

Emerg Infect Dis ; 28(1): 244-247, 2022 01.

Article in English | MEDLINE | ID: covidwho-1496968

ABSTRACT

ABSTRACT

We investigated the infectivity of 128 severe acute respiratory disease coronavirus 2-associated deaths and evaluated predictive values of standard diagnostic procedures. Maintained infectivity (20%) did not correlate with viral RNA loads but correlated well with anti-S antibody levels. Sensitivity >90% for antigen-detecting rapid diagnostic tests supports their usefulness for assessment.

Subject(s)

COVID-19; SARS-CoV-2; Autopsy; Diagnostic Tests, Routine; Humans; Sensitivity and Specificity; Viral Load

Keywords

Ag-RDT; COVID-19; SARS-CoV-2; antigen-detecting rapid diagnostic test; coronavirus; coronavirus disease 2019; infectivity; postmortem; respiratory infections; serostatus; severe acute respiratory syndrome coronavirus 2; viral RNA load; viruses; zoonoses

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Emerg Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article

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