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Newer Horizon of Mesenchymal Stem Cell-Based Therapy in the Management of SARS-CoV-2-Associated Mucormycosis: A Safe Hope for Future Medicine.
Raghav, Alok; Ali, Syed Ghazanfar; Jeong, Goo-Bo; Gautam, Kirti Amresh; Banday, Shahid; Mateen, Qazi Noorul; Tripathi, Prashant; Giri, Richa; Agarwal, Saurabh; Singh, Manish; Khan, Haris M.
  • Raghav A; Multidiscplinary Research Unit, Department of Health Research, MoHFW, GSVM Medical College, Kanpur, India.
  • Ali SG; Viral Research Diagnostic Laboratory, Department of Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, India.
  • Jeong GB; Department of Anatomy and Cell Biology, College of Medicine, Gachon University, Getbeol-ro Yeonsu-gu, Incheon, Korea.
  • Gautam KA; Multidiscplinary Research Unit, Department of Health Research, MoHFW, GSVM Medical College, Kanpur, India.
  • Banday S; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, United States.
  • Mateen QN; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi, India.
  • Tripathi P; Department of Biochemistry, GSVM Medical College, Kanpur, India.
  • Giri R; Department of Medicine, GSVM Medical College, Kanpur, India.
  • Agarwal S; Department of Medicine, GSVM Medical College, Kanpur, India.
  • Singh M; Department of Neurosciences, GSVM Medical College, Kanpur, India.
  • Khan HM; Viral Research Diagnostic Laboratory, Department of Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, India.
Front Microbiol ; 12: 738983, 2021.
Article in English | MEDLINE | ID: covidwho-1497100
ABSTRACT
SARS-CoV-2-infected patients are reported to show immunocompromised behavior that gives rise to a wide variety of complications due to impaired innate immune response, cytokine storm, and thrombo-inflammation. Prolonged use of steroids, diabetes mellitus, and diabetic ketoacidosis (DKA) are some of the factors responsible for the growth of Mucorales in such immunocompromised patients and, thus, can lead to a life-threatening condition referred to as mucormycosis. Therefore, an early diagnosis and cell-based management cosis is the need of the hour to help affected patients overcome this severe condition. In addition, extended exposure to antifungal drugs/therapeutics is found to initiate hormonal and neurological complications. More recently, mesenchymal stem cells (MSCs) have been used to exhibit immunomodulatory function and proven to be beneficial in a clinical cell-based regenerative approach. The immunomodulation ability of MSCs in mucormycosis patient boosts the immunity by the release of chemotactic proteins. MSC-based therapy in mucormycosis along with the combination of short-term antifungal drugs can be utilized as a prospective approach for mucormycosis treatment with promising outcomes. However, preclinical and in mucormyIn mucormycosis, the hyphae of clinical trials are needed to establish the precise mechanism of MSCs in mucormycosis treatment.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Front Microbiol Year: 2021 Document Type: Article Affiliation country: Fmicb.2021.738983

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Front Microbiol Year: 2021 Document Type: Article Affiliation country: Fmicb.2021.738983