Your browser doesn't support javascript.
PTSD as an Endothelial Disease: Insights From COVID-19.
Sfera, Adonis; Osorio, Carolina; Rahman, Leah; Zapata-Martín Del Campo, Carlos Manuel; Maldonado, Jose Campo; Jafri, Nyla; Cummings, Michael Allen; Maurer, Steve; Kozlakidis, Zisis.
  • Sfera A; Department of Psychiatry, Loma Linda University, Loma Linda, CA, United States.
  • Osorio C; Patton State Hospital, San Bernardino, CA, United States.
  • Rahman L; Department of Psychiatry, Loma Linda University, Loma Linda, CA, United States.
  • Zapata-Martín Del Campo CM; Patton State Hospital, San Bernardino, CA, United States.
  • Maldonado JC; Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico.
  • Jafri N; Department of Medicine, The University of Texas Rio Grande Valley, Edinburg, TX, United States.
  • Cummings MA; Patton State Hospital, San Bernardino, CA, United States.
  • Maurer S; Patton State Hospital, San Bernardino, CA, United States.
  • Kozlakidis Z; Patton State Hospital, San Bernardino, CA, United States.
Front Cell Neurosci ; 15: 770387, 2021.
Article in English | MEDLINE | ID: covidwho-1497103
ABSTRACT
SARS-CoV-2 virus, the etiologic agent of COVID-19, has affected almost every aspect of human life, precipitating stress-related pathology in vulnerable individuals. As the prevalence rate of posttraumatic stress disorder in pandemic survivors exceeds that of the general and special populations, the virus may predispose to this disorder by directly interfering with the stress-processing pathways. The SARS-CoV-2 interactome has identified several antigens that may disrupt the blood-brain-barrier by inducing premature senescence in many cell types, including the cerebral endothelial cells. This enables the stress molecules, including angiotensin II, endothelin-1 and plasminogen activator inhibitor 1, to aberrantly activate the amygdala, hippocampus, and medial prefrontal cortex, increasing the vulnerability to stress related disorders. This is supported by observing the beneficial effects of angiotensin receptor blockers and angiotensin converting enzyme inhibitors in both posttraumatic stress disorder and SARS-CoV-2 critical illness. In this narrative review, we take a closer look at the virus-host dialog and its impact on the renin-angiotensin system, mitochondrial fitness, and brain-derived neurotrophic factor. We discuss the role of furin cleaving site, the fibrinolytic system, and Sigma-1 receptor in the pathogenesis of psychological trauma. In other words, learning from the virus, clarify the molecular underpinnings of stress related disorders, and design better therapies for these conditions. In this context, we emphasize new potential treatments, including furin and bromodomains inhibitors.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Prognostic study / Reviews Language: English Journal: Front Cell Neurosci Year: 2021 Document Type: Article Affiliation country: Fncel.2021.770387

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Prognostic study / Reviews Language: English Journal: Front Cell Neurosci Year: 2021 Document Type: Article Affiliation country: Fncel.2021.770387