Association of Ethnicity With Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2 Infection: An International Case-Referent Study.
Front Pediatr
; 9: 707650, 2021.
Article
in English
| MEDLINE | ID: covidwho-1497112
ABSTRACT
Background:
It has been suggested that children and infants can develop multisystem inflammatory syndrome in children (MIS-C) in response to a SARS-CoV-2 infection and that Black children are overrepresented among cases. The aim of the current study was to quantify the association between Black, Asian, or other non-White genetic background and COVID-19-related MIS-C in children and infants.Methods:
Eight different research groups contributed cases of MIS-C, potentially related to SARS-CoV-2 infection. Several sensitivity analyses were performed, including additional data available from the literature. Analyses were stratified by geographical region.Results:
Seventy-three cases from nine distinct geographical regions were included in the primary analyses. In comparison to White children, the relative risk for developing MIS-C after SARS-CoV-2 infection was 15 [95% confidence interval (CI) 7.1 to 32] for Black children, 11 (CI 2.2 to 57) for Asian, and 1.6 (CI 0.58 to 4.2) for other ethnic background.Conclusion:
Pediatricians should be aware of the fact that the risk of COVID-19-related MIS-C is severely increased in Black children.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
English
Journal:
Front Pediatr
Year:
2021
Document Type:
Article
Affiliation country:
Fped.2021.707650
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