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Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic.
Yilmaz, Aysun; Kayar, Abdullah; Turan, Nuri; Iskefli, Onur; Bayrakal, Alper; Roman-Sosa, Gleyder; Or, Erman; Tali, Hasan Emre; Kocazeybek, Bekir; Karaali, Ridvan; Bold, Dashzeveg; Sadeyen, Jean-Remy; Lukosaityte, Deimante; Chang, Pengxiang; Iqbal, Munir; Richt, Juergen A; Yilmaz, Huseyin.
  • Yilmaz A; Department of Virology, Veterinary Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Kayar A; Department of Internal Medicine, Veterinary Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Turan N; Department of Virology, Veterinary Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Iskefli O; Department of Internal Medicine, Veterinary Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Bayrakal A; Department of Internal Medicine, Veterinary Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Roman-Sosa G; Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States.
  • Or E; Department of Internal Medicine, Veterinary Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Tali HE; Department of Virology, Veterinary Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Kocazeybek B; Department of Medical Microbiology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Karaali R; Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Bold D; Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States.
  • Sadeyen JR; Avian Influenza Group, The Pirbright Institute, Woking, United Kingdom.
  • Lukosaityte D; Avian Influenza Group, The Pirbright Institute, Woking, United Kingdom.
  • Chang P; Avian Influenza Group, The Pirbright Institute, Woking, United Kingdom.
  • Iqbal M; Avian Influenza Group, The Pirbright Institute, Woking, United Kingdom.
  • Richt JA; Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States.
  • Yilmaz H; Department of Virology, Veterinary Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Front Vet Sci ; 8: 707368, 2021.
Article in English | MEDLINE | ID: covidwho-1497189
ABSTRACT
Recent studies demonstrated that domestic cats can be naturally and experimentally infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This study was performed to investigate the presence of SARS-CoV-2-specific antibodies within the domestic cat population in Istanbul, Turkey, before the coronavirus disease 2019 (COVID-19) and during the COVID-19 pandemic. Overall, from 155 cat sera analyzed, 26.45% (41/155) tested positive in the spike protein-ELISA (S-ELISA), 28.38% (44/155) in the receptor-binding domain-ELISA (RBD-ELISA), and 21.9% (34/155) in both, the S- and RBD-ELISAs. Twenty-seven of those were also positive for the presence of antibodies to feline coronavirus (FCoV). Among the 34 SARS-CoV-2-positive sera, three of those were positive on serum neutralization assay. Six of the 30 cats before COVID-19 and 28 of the 125 cats during COVID-19 were found to be seropositive. About 20% of ELISA-positive cats exhibited mainly respiratory, gastrointestinal, and renal signs and skin lesions. Hematocrit, hemoglobin, white blood cells, lymphocyte, and platelet numbers were low in about 30% of ELISA-positive cats. The number of neutrophils and monocytes were above normal values in about 20% of ELISA-positive cats. The liver enzyme alanine aminotransferase levels were high in 23.5% ELISA-positive cats. In conclusion, this is the first report describing antibodies specific to SARS-CoV-2 antigens (S and RBD) in cats in Istanbul, Turkey, indicating the risk for domestic cats to contract SARS-CoV-2 from owners and/or household members with COVID-19. This study and others show that COVID-19-positive pet owners should limit their contact with companion animals and that pets with respiratory signs should be monitored for SARS-CoV-2 infections.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Front Vet Sci Year: 2021 Document Type: Article Affiliation country: Fvets.2021.707368

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Front Vet Sci Year: 2021 Document Type: Article Affiliation country: Fvets.2021.707368