Monoclonal Gammopathy of Undetermined Significance Clinic during the Coronavirus Disease-19 Pandemic: Caring for the Vulnerable in an Academic Medical Center.
Rev Invest Clin
; 73(4): 259-264, 2021 06 02.
Article
in English
| MEDLINE | ID: covidwho-1498287
ABSTRACT
BACKGROUND:
Patients with monoclonal gammopathy of undetermined significance (MGUS) have clinical features including older age, presence of medical comorbidities, susceptibility to infections, and thrombotic tendencies which are relevant when assessing their risk during the coronavirus disease (COVID-19) pandemic.OBJECTIVE:
To study the vulnerability of patients with MGUS during the COVID-19 pandemic, we assessed the local management of MGUS patients and their clinical outcomes.METHODS:
Retrospective chart reviews were performed for all patients with MGUS seen at a university medical center clinic (2014-2020).RESULTS:
A total of 228 MGUS patients were included; 211 patients are alive, 7 patients died before the pandemic, and 10 patients died since the pandemic declaration. The mean age and the overall survival (OS) of the patients who died before versus during the pandemic were 83.0 versus 75.2 years, p = 0.4, and OS 40.6 versus 53.2 months, p = 0.3, respectively. One patient died of COVID-19. Nine patients had venous thromboembolisms (VTE), all of which occurred before the pandemic onset.CONCLUSIONS:
There were no significant differences found in the mean age or OS of the MGUS patients who died before versus after the pandemic onset. An increase in VTE rates was not seen. Study results are limited by small patient numbers.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Monoclonal Gammopathy of Undetermined Significance
/
Venous Thromboembolism
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev Invest Clin
Journal subject:
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
RIC.21000078
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