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Identification of key factors shaping integrated levels of ACE2 and TMPRSS2 expression in head and neck squamous cell carcinoma.
Zheng, Tianyu; Yue, Peipei; Han, Tongtong; Zhang, Kaige; Jiang, Yiming; Wang, Sijian; Jiang, Lulu; Zhao, Baohong; Zhang, Xinwen; Yan, Xu.
  • Zheng T; The VIP Department, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, 110002 Shenyang, Liaoning, China.
  • Yue P; Department of Emergency and General, Dalian Stomatological Hospital, 116083 Dalian, Liaoning, China.
  • Han T; Department of Laboratory Medicine, The Fourth Affiliated Hospital, China Medical University, 110032 Shenyang, Liaoning, China.
  • Zhang K; The VIP Department, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, 110002 Shenyang, Liaoning, China.
  • Jiang Y; Center of Implant Dentistry, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, 110002 Shenyang, Liaoning, China.
  • Wang S; The VIP Department, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, 110002 Shenyang, Liaoning, China.
  • Jiang L; Center of Implant Dentistry, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, 110002 Shenyang, Liaoning, China.
  • Zhao B; Center of Implant Dentistry, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, 110002 Shenyang, Liaoning, China.
  • Zhang X; Center of Implant Dentistry, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, 110002 Shenyang, Liaoning, China.
  • Yan X; Center of Implant Dentistry, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, 110002 Shenyang, Liaoning, China.
Front Biosci (Landmark Ed) ; 26(10): 740-751, 2021 10 30.
Article in English | MEDLINE | ID: covidwho-1498507
ABSTRACT

Objectives:

To quantify the integrated levels of ACE2 and TMPRSS2, the two well-recognized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry-related genes, and to further identify key factors contributing to SARS-CoV-2 susceptibility in head and neck squamous cell carcinoma (HNSC).

Methods:

We developed a metric of the potential for tissue infected with SARS-CoV-2 ("TPSI") based on ACE2 and TMPRSS2 transcript levels and compared TPSI levels between tumor and matched normal tissues across 11 tumor types. For further analysis of HNSC, weighted gene co-expression network analysis (WGCNA), functional analysis, and single sample gene set enrichment analysis (ssGSEA) were conducted to investigate TPSI-relevant biological processes and their relationship with the immune landscape. TPSI-related factors were identified from clinical and mutational domains, followed by lasso regression to determine their relative effects on TPSI levels.

Results:

TPSI levels in tumors were generally lower than in the normal tissues. In HNSC, the genes highly associated with TPSI were enriched in viral entry-related processes, and TPSI levels were positively correlated with both eosinophils and T helper 17 (Th17) cell infiltration. Furthermore, the site of onset, human papillomaviruses (HPV) status, and nuclear receptor binding SET domain protein 1 (NSD1) mutations were identified as the most important factors shaping TPSI levels.

Conclusions:

This study identified the infection risk of SARS-CoV-2 between tumor and normal tissues, and provided evidence for the risk stratification of HNSC.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serine Endopeptidases / Carcinoma, Squamous Cell / Angiotensin-Converting Enzyme 2 / COVID-19 / Head and Neck Neoplasms Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Front Biosci (Landmark Ed) Year: 2021 Document Type: Article Affiliation country: 4984

Full text: Available Collection: International databases Database: MEDLINE Main subject: Serine Endopeptidases / Carcinoma, Squamous Cell / Angiotensin-Converting Enzyme 2 / COVID-19 / Head and Neck Neoplasms Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Front Biosci (Landmark Ed) Year: 2021 Document Type: Article Affiliation country: 4984