Potential roles of mesenchymal stem cells and their exosomes in the treatment of COVID-19.
Front Biosci (Landmark Ed)
; 26(10): 948-961, 2021 10 30.
Article
in English
| MEDLINE | ID: covidwho-1498509
ABSTRACT
Background:
Corona Virus Disease 2019 (COVID-19) is an acute respiratory infectious disease caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2). The primary pathogenesis is over-activation of the immune system. SARS-CoV-2 continues to mutate and spread rapidly and no effective treatment options are yet available. Mesenchymal stem cells (MSCs) are known to induce anti-inflammatory macrophages, regulatory T cells and dendritic cells. There are a rapidly increasing number of clinical investigations of cell-based therapy approaches for COVID-19.Objective:
To summarize the pathogenic mechanism of SARS-CoV-2, and systematically formulated the immunomodulation of COVID-19 by MSCs and their exosomes, as well as research progress.Method:
Searching PubMed, clinicaltrials.gov and Chictr.cn for eligible studies to be published or registered by May 2021. Main keywords and search strategies were as follows ((Mesenchymal stem cells) OR (MSCs)) AND (COVID-19).Results:
MSCs regulate the immune system to prevent cytokine release syndrome (CRS) and to promote endogenous repair by releasing various paracrine factors and exosomes.Conclusions:
MSC therapy is thus a promising candidate for COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Mesenchymal Stem Cell Transplantation
/
Exosomes
/
Lung Injury
/
Immunomodulation
/
Mesenchymal Stem Cells
/
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
Limits:
Humans
Language:
English
Journal:
Front Biosci (Landmark Ed)
Year:
2021
Document Type:
Article
Affiliation country:
4999
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