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A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin.
Justice, Jamie N; Gubbi, Sriram; Kulkarni, Ameya S; Bartley, Jenna M; Kuchel, George A; Barzilai, Nir.
  • Justice JN; Sticht Center for Healthy Aging and Alzheimer's Prevention, Internal Medicine - Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA. jnjustic@wakehealth.edu.
  • Gubbi S; Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20814, USA.
  • Kulkarni AS; Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
  • Bartley JM; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
  • Kuchel GA; Center on Aging, University of Connecticut School of Medicine, Farmington, CT, 06030, USA.
  • Barzilai N; Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, 06030, USA.
Geroscience ; 43(3): 1093-1112, 2021 06.
Article in English | MEDLINE | ID: covidwho-1499503
Semantic information from SemMedBD (by NLM)
1. Coronavirus Infections CAUSES COVID-19
Subject
Coronavirus Infections
Predicate
CAUSES
Object
COVID-19
2. Coronavirus Infections OCCURS_IN Elderly (population group)
Subject
Coronavirus Infections
Predicate
OCCURS_IN
Object
Elderly (population group)
3. Syndrome PROCESS_OF Old age
Subject
Syndrome
Predicate
PROCESS_OF
Object
Old age
4. Communicable Diseases CAUSES Syndrome
Subject
Communicable Diseases
Predicate
CAUSES
Object
Syndrome
5. Coronavirus Infections CAUSES COVID-19
Subject
Coronavirus Infections
Predicate
CAUSES
Object
COVID-19
6. Coronavirus Infections OCCURS_IN Elderly (population group)
Subject
Coronavirus Infections
Predicate
OCCURS_IN
Object
Elderly (population group)
7. Syndrome PROCESS_OF Old age
Subject
Syndrome
Predicate
PROCESS_OF
Object
Old age
8. Communicable Diseases CAUSES Syndrome
Subject
Communicable Diseases
Predicate
CAUSES
Object
Syndrome
ABSTRACT
We are in the midst of the global pandemic. Though acute respiratory coronavirus (SARS-COV2) that leads to COVID-19 infects people of all ages, severe symptoms and mortality occur disproportionately in older adults. Geroscience interventions that target biological aging could decrease risk across multiple age-related diseases and improve outcomes in response to infectious disease. This offers hope for a new host-directed therapeutic approach that could (i) improve outcomes following exposure or shorten treatment regimens; (ii) reduce the chronic pathology associated with the infectious disease and subsequent comorbidity, frailty, and disability; and (iii) promote development of immunological memory that protects against relapse or improves response to vaccination. We review the possibility of this approach by examining available evidence in metformin a generic drug with a proven safety record that will be used in a large-scale multicenter clinical trial. Though rigorous translational research and clinical trials are needed to test this empirically, metformin may improve host immune defenses and confer protection against long-term health consequences of infectious disease, age-related chronic diseases, and geriatric syndromes.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 / Metformin Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Aged / Humans Language: English Journal: Geroscience Year: 2021 Document Type: Article Affiliation country: S11357-020-00261-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 / Metformin Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Aged / Humans Language: English Journal: Geroscience Year: 2021 Document Type: Article Affiliation country: S11357-020-00261-6