Roles of the tissue-type plasminogen activator in immune response.
Cell Immunol
; 371: 104451, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1499702
ABSTRACT
The COVID-19 pandemic has once again brought to the forefront the existence of a tight link between the coagulation/fibrinolytic system and the immunologic processes. Tissue-type plasminogen activator (tPA) is a serine protease with a key role in fibrinolysis by converting plasminogen into plasmin that can finally degrade fibrin clots. tPA is released in the blood by endothelial cells and hepatocytes but is also produced by various types of immune cells including T cells and monocytes. Beyond its role on hemostasis, tPA is also a potent modulator of inflammation and is involved in the regulation of several inflammatory diseases. Here, after a brief description of tPA structure, we review its new functions in adaptive immunity focusing on T cells and antigen presenting cells. We intend to synthesize the recent knowledge on proteolysis- and receptor-mediated effects of tPA on immune response in physiological and pathological context.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Blood Coagulation
/
Tissue Plasminogen Activator
/
Fibrinolysis
/
SARS-CoV-2
/
COVID-19
/
Immunity
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Cell Immunol
Year:
2022
Document Type:
Article
Affiliation country:
J.cellimm.2021.104451
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