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Virucidal activity of nasal sprays against severe acute respiratory syndrome coronavirus-2.
Meister, T L; Todt, D; Brüggemann, Y; Steinmann, J; Banava, S; Brill, F H H; Steinmann, J; Pfaender, S; Steinmann, E.
  • Meister TL; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.
  • Todt D; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany; European Virus Bioinformatics Centre, Jena, Germany.
  • Brüggemann Y; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.
  • Steinmann J; Institute of Clinical Hygiene, Medical Microbiology and Infectiology, General Hospital Nürnberg, Paracelsus Medical University, Nuremberg, Germany; Institute of Medical Microbiology, University Hospital of Essen, Essen, Germany.
  • Banava S; Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, CA, USA.
  • Brill FHH; Dr. Brill + Partner GmbH Institute for Hygiene and Microbiology, Hamburg, Germany.
  • Steinmann J; Dr. Brill + Partner GmbH Institute for Hygiene and Microbiology, Hamburg, Germany.
  • Pfaender S; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.
  • Steinmann E; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany. Electronic address: eike.steinmann@ruhr-uni-bochum.de.
J Hosp Infect ; 120: 9-13, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1500052
ABSTRACT
The highest viral loads of severe acute respiratory syndrome coronavirus-2 are detectable in the oral cavity, so a potential reduction of infectious virus by nasal and oral sprays could reduce transmission. Therefore, the inactivation capacity of nine nasal and oral sprays was evaluated according to EN 14476. One nasal spray based on sodium hypochlorite and one oral spray containing essential oils reduced viral titres by two to three orders of magnitude. Although clinical data are still sparse, nasal and oral sprays display a more convenient application for elderly people or those who are unable to rinse/gargle.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nasal Sprays / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Aged / Humans Language: English Journal: J Hosp Infect Year: 2022 Document Type: Article Affiliation country: J.jhin.2021.10.019

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nasal Sprays / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Aged / Humans Language: English Journal: J Hosp Infect Year: 2022 Document Type: Article Affiliation country: J.jhin.2021.10.019