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Drug resistance in Candida albicans isolates and related changes in the structural domain of Mdr1 protein.
Dhasarathan, P; AlSalhi, Mohamad S; Devanesan, Sandhanasamy; Subbiah, Jeeva; Ranjitsingh, A J A; Binsalah, Mohammed; Alfuraydi, Akram A.
  • Dhasarathan P; Department of Biotechnology, Prathyusha Engineering College, Thiruvallur 602 025, Tamil Nadu, India.
  • AlSalhi MS; Department of Physics and Astronomy, College of Science, King Saud University, P.O. Box-2455, Riyadh, 11451, Saudi Arabia. Electronic address: malsalhi@ksu.edu.sa.
  • Devanesan S; Department of Physics and Astronomy, College of Science, King Saud University, P.O. Box-2455, Riyadh, 11451, Saudi Arabia.
  • Subbiah J; Department Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
  • Ranjitsingh AJA; Department of Biotechnology, Prathyusha Engineering College, Thiruvallur 602 025, Tamil Nadu, India. Electronic address: ranjitspkc@gmail.com.
  • Binsalah M; Department of Oral and Maxillofacial Surgery, College of Dentistry, King Saud University, Riyadh, 11451, Saudi Arabia.
  • Alfuraydi AA; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box-2455, Riyadh, 11451, Saudi Arabia.
J Infect Public Health ; 14(12): 1848-1853, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1500076
ABSTRACT

BACKGROUND:

The increasing azole drug resistance in fungal pathogens poses a pressing threat to global health care. The coexistence of drug-resistant Candida albicans with tuberculosis patients and the failure of several drugs to treat C. albicans infection extend hospital stay, economic burden, and death. The misuse or abuse of azole-derived antifungals, chronic use of TB drugs, different immune-suppressive drugs, and diseases like HIV, COVID-19, etc., have aggravated the situation. So it is vital to understand the molecular changes in drug-resistant genes to modify the treatment to design an alternative mechanism.

METHOD:

C. albicans isolated from chronic tuberculosis patients were screened for antifungal sensitivity studies using disk diffusion assay. The multidrug-resistant C. albicans were further screened for molecular-level changes in drug resistance using MDR1 gene sequencing and compared with Gen bank data of similar species using the BLAST tool.

RESULTS:

The investigation proved that the isolated C. albicans from TB patients are significantly resistant to the action of six drugs. The molecular changes in MDR1 genes showed differences in seven nucleotide base pairs that interfered with the efflux pump.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Candida albicans / COVID-19 Topics: Variants Limits: Humans Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2021 Document Type: Article Affiliation country: J.jiph.2021.11.002

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Candida albicans / COVID-19 Topics: Variants Limits: Humans Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2021 Document Type: Article Affiliation country: J.jiph.2021.11.002