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Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes.
Kukla, Michal; Menzyk, Tomasz; Dembinski, Marcin; Winiarski, Marek; Garlicki, Aleksander; Bociaga-Jasik, Monika; Skonieczna, Magdalena; Hudy, Dorota; Maziarz, Barbara; Kusnierz-Cabala, Beata; Skladany, Lubomir; Grgurevic, Ivica; Wójcik-Bugajska, Malgorzata; Grodzicki, Tomasz; Stygar, Dominika; Rogula, Tomasz.
  • Kukla M; Department of Internal Medicine and Geriatrics, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland.
  • Menzyk T; Department of Endoscopy, University Hospital in Kraków, Cracow, Poland.
  • Dembinski M; Department of Internal Medicine, Gastroenterology and Acute Intoxication, Regional Hospital, Tarnów, Poland.
  • Winiarski M; Department of Endoscopy, University Hospital in Kraków, Cracow, Poland.
  • Garlicki A; 2nd Department of General Surgery, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland.
  • Bociaga-Jasik M; Department of Endoscopy, University Hospital in Kraków, Cracow, Poland.
  • Skonieczna M; 2nd Department of General Surgery, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland.
  • Hudy D; Chair of Gastroenterology, Hepatology and Infectious Diseases, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland.
  • Maziarz B; Chair of Gastroenterology, Hepatology and Infectious Diseases, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland.
  • Kusnierz-Cabala B; Department of Systems Biology and Engineering, Silesian University of Technology, 44-100, Gliwice, Poland.
  • Skladany L; Biotechnology Centre, Silesian University of Technology, 44-100, Gliwice, Poland.
  • Grgurevic I; Department of Systems Biology and Engineering, Silesian University of Technology, 44-100, Gliwice, Poland.
  • Wójcik-Bugajska M; Biotechnology Centre, Silesian University of Technology, 44-100, Gliwice, Poland.
  • Grodzicki T; Chair of Clinical BioChemistry, Department of Diagnostics, Faculty of Medicine, Jagiellonian University Medical College, 31-501, Cracow, Poland.
  • Stygar D; Chair of Clinical BioChemistry, Department of Diagnostics, Faculty of Medicine, Jagiellonian University Medical College, 31-501, Cracow, Poland.
  • Rogula T; Department of Internal Medicine and HEGITO (Hepatology, Gastroenterology and Liver Transplantation), F.D. Roosevelt University Hospital, Banska Bystrica, Slovakia.
Sci Rep ; 11(1): 21514, 2021 11 02.
Article in English | MEDLINE | ID: covidwho-1500512
ABSTRACT
Coronavirus disease 2019 (COVID-19) is associated with systemic inflammation. A wide range of adipokines activities suggests they influence pathogenesis and infection course. The aim was to assess concentrations of chemerin, omentin, and vaspin among COVID-19 patients with an emphasis on adipokines relationship with COVID-19 severity, concomitant metabolic abnormalities and liver dysfunction. Serum chemerin, omentin and vaspin concentrations were measured in serum collected from 70 COVID-19 patients at the moment of admission to hospital, before any treatment was applied and 20 healthy controls. Serum chemerin and omentin concentrations were significantly decreased in COVID-19 patients compared to healthy volunteers (271.0 vs. 373.0 ng/ml; p < 0.001 and 482.1 vs. 814.3 ng/ml; p = 0.01, respectively). There were no correlations of analyzed adipokines with COVID-19 severity based on the presence of pneumonia, dyspnea, or necessity of Intensive Care Unit hospitalization (ICU). Liver test abnormalities did not influence adipokines levels. Elevated GGT activity was associated with ICU admission, presence of pneumonia and elevated concentrations of CRP, ferritin and interleukin 6. Chemerin and omentin depletion in COVID-19 patients suggests that this adipokines deficiency play influential role in disease pathogenesis. However, there was no relationship between lower adipokines level and frequency of COVID-19 symptoms as well as disease severity. The only predictive factor which could predispose to a more severe COVID-19 course, including the presence of pneumonia and ICU hospitalization, was GGT activity.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Serpins / Cytokines / Chemokines / Adipokines / Lectins Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-00928-w

Full text: Available Collection: International databases Database: MEDLINE Main subject: Serpins / Cytokines / Chemokines / Adipokines / Lectins Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-00928-w