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PaO2/FiO2 and IL-6 are risk factors of mortality for intensive care COVID-19 patients.
Gu, Yanli; Wang, Donghui; Chen, Cen; Lu, Wanjun; Liu, Hongbing; Lv, Tangfeng; Song, Yong; Zhang, Fang.
  • Gu Y; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, 210002, China.
  • Wang D; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, 210002, China.
  • Chen C; Department of Respiratory and Critical Care Medicine, The First School of Clinical Medicine, Jinling Hospital, Southern Medical University, Nanjing, 210002, China.
  • Lu W; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China.
  • Liu H; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China.
  • Lv T; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China.
  • Song Y; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, 210002, China. yong.song@nju.edu.cn.
  • Zhang F; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China. yong.song@nju.edu.cn.
Sci Rep ; 11(1): 7334, 2021 04 01.
Article in English | MEDLINE | ID: covidwho-1500696
Semantic information from SemMedBD (by NLM)
1. Cessation of life PROCESS_OF Patients
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Patients
2. Cessation of life PROCESS_OF Patients
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
To identify the risk factors of mortality for the coronavirus disease 19 (COVID-19) patients admitted to intensive care units (ICUs) through a retrospective analysis. The demographic, clinical, laboratory, and chest imaging data of patients admitted to the ICU of Huoshenshan Hospital from February 10 to April 10, 2020 were retrospectively analyzed. Student's t-test and Chi-square test were used to compare the continuous and categorical variables, respectively. The logistic regression model was employed to ascertain the risk factors of mortality. This retrospective study involved 123 patients, including 64 dead and 59 survivors. Among them, 57 people were tested for interleukin-6 (IL-6) (20 died and 37 survived). In all included patients, the oxygenation index (PaO2/FiO2) was identified as an independent risk factor (odd ratio [OR] = 0.96, 95% confidence interval [CI] 0.928-0.994, p = 0.021). The area under the curve (AUC) was 0.895 (95% CI 0.826-0.943, p < 0.0001). Among the patients tested for IL-6, the PaO2/FiO2 (OR = 0.955, 95%CI 0.915-0.996, p = 0.032) and IL-6 (OR = 1.013, 95%CI 1.001-1.025, p = 0.028) were identified as independent risk factors. The AUC was 0.9 (95% CI 0.791-0.964, p < 0.0001) for IL-6 and 0.865 (95% CI 0.748-0.941, p < 0.0001) for PaO2/FiO2. PaO2/FiO2 and IL-6 could potentially serve as independent risk factors for predicting death in COVID-19 patients requiring intensive care.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Interleukin-6 / COVID-19 Subject: Interleukin-6 / COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Risk factors Language: English Journal: Sci Rep Clinical aspect: Etiology / Prediction / Prognosis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Interleukin-6 / COVID-19 Subject: Interleukin-6 / COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Risk factors Language: English Journal: Sci Rep Clinical aspect: Etiology / Prediction / Prognosis Year: 2021
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