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Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2.
Byun, Wan Gi; Lee, Jihye; Kim, Seungtaek; Park, Seung Bum.
  • Byun WG; CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Korea. sbpark@snu.ac.kr.
  • Lee J; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam 13488, Korea.
  • Kim S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam 13488, Korea.
  • Park SB; CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Korea. sbpark@snu.ac.kr.
Chem Commun (Camb) ; 57(93): 12476-12479, 2021 Nov 23.
Article in English | MEDLINE | ID: covidwho-1500757
ABSTRACT
We identified small-molecule enhancers of cellular stress granules by observing molecular crowding of proteins and RNAs in a time-dependent manner. Hit molecules sensitized the IRF3-mediated antiviral mechanism in the presence of poly(IC) and inhibited the replication of SARS-CoV-2 by inducing stress granule formation. Thus, modulating multimolecular crowding can be a promising strategy against SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pyrazoles / Virus Replication / Benzopyrans / Cytoplasmic Granules / SARS-CoV-2 Limits: Animals / Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pyrazoles / Virus Replication / Benzopyrans / Cytoplasmic Granules / SARS-CoV-2 Limits: Animals / Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2021 Document Type: Article