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Using in vivo animal models for studying SARS-CoV-2.
Da Costa, Camila B P; Cruz, Ana Claudia De Menezes; Penha, Julio Cesar Q; Castro, Helena C; Da Cunha, Luis E R; Ratcliffe, Norman A; Cisne, Rafael; Martins, Francislene Juliana.
  • Da Costa CBP; Technological Development and Innovation Laboratory of the Industrial Board, Instituto Vital Brazil, Rio De Janeiro, Brazil.
  • Cruz ACM; Programa de Pós-graduação em Ciências e Biotecnologia, IB, UFF, Rio de Janeiro, Brazil.
  • Penha JCQ; Programa de Pós-graduação em Ciências e Biotecnologia, IB, UFF, Rio de Janeiro, Brazil.
  • Castro HC; Programa de Pós-graduação em Ciências e Biotecnologia, IB, UFF, Rio de Janeiro, Brazil.
  • Da Cunha LER; Programa de Pós-graduação em Ciências e Biotecnologia, IB, UFF, Rio de Janeiro, Brazil.
  • Ratcliffe NA; Technological Development and Innovation Laboratory of the Industrial Board, Instituto Vital Brazil, Rio De Janeiro, Brazil.
  • Cisne R; Programa de Pós-graduação em Ciências e Biotecnologia, IB, UFF, Rio de Janeiro, Brazil.
  • Martins FJ; Department of Biociences, College of Science, Swansea University, Swansea, UK.
Expert Opin Drug Discov ; 17(2): 121-137, 2022 02.
Article in English | MEDLINE | ID: covidwho-1500936
ABSTRACT

INTRODUCTION:

The search for an animal model capable of reproducing the physiopathology of the COVID-19, and also suitable for evaluating the efficacy and safety of new drugs has become a challenge for many researchers. AREAS COVERED This work reviews the current animal models for in vivo tests with SARS-CoV-2 as well as the challenges involved in the safety and efficacy trials. EXPERT OPINION Studies have reported the use of nonhuman primates, ferrets, mice, Syrian hamsters, lagomorphs, mink, and zebrafish in experiments that aimed to understand the course of COVID-19 or test vaccines and other drugs. In contrast, the assays with animal hyperimmune sera have only been used in in vitro assays. Finding an animal that faithfully reproduces all the characteristics of the disease in humans is difficult. Some models may be more complex to work with, such as monkeys, or require genetic manipulation so that they can express the human ACE2 receptor, as in the case of mice. Although some models are more promising, possibly the use of more than one animal model represents the best scenario. Therefore, further studies are needed to establish an ideal animal model to help in the development of other treatment strategies besides vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Expert Opin Drug Discov Year: 2022 Document Type: Article Affiliation country: 17460441.2022.1995352

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Expert Opin Drug Discov Year: 2022 Document Type: Article Affiliation country: 17460441.2022.1995352