Specific Redistribution of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Respiratory System and Intestinal Tract.

Du, Pengcheng; Song, Chuan; Li, Rui; Song, Yangzi; Li, Jiarui; Ding, Nan; Zhang, Ju; Song, Rui; Han, Junyan; Gao, Guiju; Yue, Jinglin; Duan, Ang; Huang, Yanyi; An, Jing; Wang, Jianbin; Zhang, Fujie; Chen, Chen; Zeng, Hui

Du, Pengcheng; Song, Chuan; Li, Rui; Song, Yangzi; Li, Jiarui; Ding, Nan; Zhang, Ju; Song, Rui; Han, Junyan; Gao, Guiju; Yue, Jinglin; Duan, Ang; Huang, Yanyi; An, Jing; Wang, Jianbin; Zhang, Fujie; Chen, Chen; Zeng, Hui.

Du P; Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Song C; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, People's Republic of China.
Li R; Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Song Y; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, People's Republic of China.
Li J; Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Ding N; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, People's Republic of China.
Zhang J; Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Song R; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, People's Republic of China.
Han J; Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Gao G; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, People's Republic of China.
Yue J; Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Duan A; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, People's Republic of China.
Huang Y; Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
An J; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, People's Republic of China.
Wang J; Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Zhang F; Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Chen C; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, People's Republic of China.
Zeng H; Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.

Clin Infect Dis ; 73(9): e2814-e2817, 2021 11 02.

Article in English | MEDLINE | ID: covidwho-1501023

ABSTRACT

ABSTRACT

Intrahost analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic sequences identified 2 viral haplotypes comprised of 3 genetically linked mutations from the respiratory and intestinal tracts of a patient with coronavirus disease 2019. Spatiotemporal data suggest that this patient initially had dual infection of 2 SARS-CoV-2 variants, which subsequently redistributed into the 2 systems.

Subject(s)

COVID-19; SARS-CoV-2; Genomics; Humans; Respiratory System

Keywords

SARS-CoV-2; dual infection; organ-specific redistribution; severe acute respiratory syndrome coronavirus 2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Variants Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article

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