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Risk Factors for Testing Positive for Severe Acute Respiratory Syndrome Coronavirus 2 in a National United States Healthcare System.
Fan, Vincent S; Dominitz, Jason A; Eastment, McKenna C; Locke, Emily R; Green, Pamela; Berry, Kristin; O'Hare, Ann M; Shah, Javeed A; Crothers, Kristina; Ioannou, George N.
  • Fan VS; Division of Pulmonary and Critical Care, Veterans Affairs Puget Sound Healthcare System and University of Washington, Seattle, Washington, USA.
  • Dominitz JA; Division of Gastroenterology, Veterans Affairs Puget Sound Healthcare System and University of Washington, Seattle, Washington, USA.
  • Eastment MC; Division of Allergy and Infectious Diseases, Veterans Affairs Puget Sound Healthcare System and University of Washington, Seattle, Washington, USA.
  • Locke ER; Research and Development, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington, USA.
  • Green P; Research and Development, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington, USA.
  • Berry K; Research and Development, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington, USA.
  • O'Hare AM; Division of Nephrology, Veterans Affairs Puget Sound Healthcare System and University of Washington, Seattle, Washington, USA.
  • Shah JA; Division of Allergy and Infectious Diseases, Veterans Affairs Puget Sound Healthcare System and University of Washington, Seattle, Washington, USA.
  • Crothers K; Division of Pulmonary and Critical Care, Veterans Affairs Puget Sound Healthcare System and University of Washington, Seattle, Washington, USA.
  • Ioannou GN; Division of Gastroenterology, Veterans Affairs Puget Sound Healthcare System and University of Washington, Seattle, Washington, USA.
Clin Infect Dis ; 73(9): e3085-e3094, 2021 11 02.
Article in English | MEDLINE | ID: covidwho-1501024
Semantic information from SemMedBD (by NLM)
1. Nucleic Acids PART_OF 2019 novel coronavirus
Subject
Nucleic Acids
Predicate
PART_OF
Object
2019 novel coronavirus
2. Obesity PREDISPOSES Co-morbid conditions
Subject
Obesity
Predicate
PREDISPOSES
Object
Co-morbid conditions
3. Nucleic Acids PART_OF 2019 novel coronavirus
Subject
Nucleic Acids
Predicate
PART_OF
Object
2019 novel coronavirus
4. Obesity PREDISPOSES Co-morbid conditions
Subject
Obesity
Predicate
PREDISPOSES
Object
Co-morbid conditions
ABSTRACT

BACKGROUND:

Identifying risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection could help health systems improve testing and screening strategies. The aim of this study was to identify demographic factors, comorbid conditions, and symptoms independently associated with testing positive for SARS-CoV-2.

METHODS:

This was an observational cross-sectional study at the Veterans Health Administration, including persons tested for SARS-CoV-2 nucleic acid by polymerase chain reaction (PCR) between 28 February and 14 May 2020. Associations between demographic characteristics, diagnosed comorbid conditions, and documented symptoms with testing positive for SARS-CoV-2 were measured.

RESULTS:

Of 88 747 persons tested, 10 131 (11.4%) were SARS-CoV-2 PCR positive. Positivity was associated with older age (≥80 vs <50 years adjusted odds ratio [aOR], 2.16 [95% confidence interval {CI}, 1.97-2.37]), male sex (aOR, 1.45 [95% CI, 1.34-1.57]), regional SARS-CoV-2 burden (≥2000 vs <400 cases/million aOR, 5.43 [95% CI, 4.97-5.93]), urban residence (aOR, 1.78 [95% CI, 1.70-1.87]), black (aOR, 2.15 [95% CI, 2.05-2.26]) or American Indian/Alaska Native Hawaiian/Pacific Islander (aOR, 1.26 [95% CI, 1.05-1.52]) vs white race, and Hispanic ethnicity (aOR, 1.52 [95% CI, 1.40-1.65]). Obesity and diabetes were the only 2 medical conditions associated with testing positive. Documented fevers, chills, cough, and diarrhea were also associated with testing positive. The population attributable fraction of positive tests was highest for geographic location (35.3%), followed by demographic variables (27.1%), symptoms (12.0%), obesity (10.5%), and diabetes (0.4%).

CONCLUSIONS:

The majority of positive SARS-CoV-2 tests were attributed to geographic location, demographic characteristics, and obesity, with a minor contribution of chronic comorbid conditions.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Etiology study / Prevalence study / Prognostic study / Randomized controlled trials / Risk factors Limits: Aged / Humans / Male Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Etiology study / Prevalence study / Prognostic study / Randomized controlled trials / Risk factors Limits: Aged / Humans / Male Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid