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Recurrence of COVID-19 in a Patient With NMO Spectrum Disorder While Treating With Rituximab: A Case Report and Review of the Literature.
Paybast, Sepideh; Shahrab, Fereshteh; Hejazi, Seyed A.
  • Paybast S; Neuroscience Research Center.
  • Shahrab F; Neurology Department, Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran.
  • Hejazi SA; Neuroscience Research Center.
Neurologist ; 26(6): 281-283, 2021 Nov 04.
Article in English | MEDLINE | ID: covidwho-1501231
ABSTRACT

INTRODUCTION:

In the context of coronavirus disease 2019 (COVID-19) pandemic, patients with neuromyelitis optica spectrum disorder (NMOSD) are vulnerable to develop COVID-19 due to the immunosuppressive therapy. The objective of this study is to describe a known case of NMOSD on rituximab who experienced 2 episodes of COVID-19. CASE REPORT A 25-year-old woman, a known case of NMOSD on rituximab was diagnosed with asymptomatic COVID-19. Eight months later, following her last infusion of rituximab, she developed moderate COVID-19. After a partial recovery, she exhibited exacerbation of respiratory symptoms leading to readmission and invasive oxygenation. She was eventually discharged home after 31 days. Her monthly neurological evaluation did not reveal evidence of disease activity. She later received intravenous immunoglobulin and the decision was made to start rituximab again.

CONCLUSIONS:

Our case raises the possibility of persistent virus shedding and reactivation of severe acute respiratory syndrome coronavirus-2 in a patient with NMOSD and rituximab therapy. We aimed to emphasize a precise consideration of management of patients with NMOSD during the COVID-19 pandemic.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuromyelitis Optica / Rituximab / Reinfection / COVID-19 Type of study: Case report / Diagnostic study / Experimental Studies Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: Neurologist Journal subject: Neurology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuromyelitis Optica / Rituximab / Reinfection / COVID-19 Type of study: Case report / Diagnostic study / Experimental Studies Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: Neurologist Journal subject: Neurology Year: 2021 Document Type: Article