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Tools and Techniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 Detection.
Safiabadi Tali, Seyed Hamid; LeBlanc, Jason J; Sadiq, Zubi; Oyewunmi, Oyejide Damilola; Camargo, Carolina; Nikpour, Bahareh; Armanfard, Narges; Sagan, Selena M; Jahanshahi-Anbuhi, Sana.
  • Safiabadi Tali SH; Department of Chemical and Materials Engineering, Gina Cody School of Engineering, Concordia University, Montréal, Québec, Canada.
  • LeBlanc JJ; Department of Mechanical, Industrial, and Aerospace Engineering, Gina Cody School of Engineering, Concordia University, Montréal, Québec, Canada.
  • Sadiq Z; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada jason.leblanc@nshealth.ca sana.anbuhi@concordia.ca.
  • Oyewunmi OD; Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Camargo C; Department of Medicine (Infectious Diseases), Dalhousie University, Halifax, Nova Scotia, Canada.
  • Nikpour B; Division of Microbiology, Department of Pathology and Laboratory Medicine, Nova Scotia Health, Halifax, Nova Scotia, Canada.
  • Armanfard N; Department of Chemical and Materials Engineering, Gina Cody School of Engineering, Concordia University, Montréal, Québec, Canada.
  • Sagan SM; Department of Chemical and Materials Engineering, Gina Cody School of Engineering, Concordia University, Montréal, Québec, Canada.
  • Jahanshahi-Anbuhi S; Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada.
Clin Microbiol Rev ; 34(3)2021 06 16.
Article in English | MEDLINE | ID: covidwho-1501523
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory disease coronavirus 2 (SARS-CoV-2), has led to millions of confirmed cases and deaths worldwide. Efficient diagnostic tools are in high demand, as rapid and large-scale testing plays a pivotal role in patient management and decelerating disease spread. This paper reviews current technologies used to detect SARS-CoV-2 in clinical laboratories as well as advances made for molecular, antigen-based, and immunological point-of-care testing, including recent developments in sensor and biosensor devices. The importance of the timing and type of specimen collection is discussed, along with factors such as disease prevalence, setting, and methods. Details of the mechanisms of action of the various methodologies are presented, along with their application span and known performance characteristics. Diagnostic imaging techniques and biomarkers are also covered, with an emphasis on their use for assessing COVID-19 or monitoring disease severity or complications. While the SARS-CoV-2 literature is rapidly evolving, this review highlights topics of interest that have occurred during the pandemic and the lessons learned throughout. Exploring a broad armamentarium of techniques for detecting SARS-CoV-2 will ensure continued diagnostic support for clinicians, public health, and infection prevention and control for this pandemic and provide advice for future pandemic preparedness.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Nucleic Acid Testing / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal subject: Microbiology Year: 2021 Document Type: Article Affiliation country: Cmr.00228-20

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Nucleic Acid Testing / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal subject: Microbiology Year: 2021 Document Type: Article Affiliation country: Cmr.00228-20