Switching Sides: How Endogenous Retroviruses Protect Us from Viral Infections.
J Virol
; 95(12)2021 05 24.
Article
in English
| MEDLINE | ID: covidwho-1501541
ABSTRACT
Long disregarded as junk DNA or genomic dark matter, endogenous retroviruses (ERVs) have turned out to represent important components of the antiviral immune response. These remnants of once-infectious retroviruses not only regulate cellular immune activation, but may even directly target invading viral pathogens. In this Gem, we summarize mechanisms by which retroviral fossils protect us from viral infections. One focus will be on recent advances in the role of ERVs as regulators of antiviral gene expression.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Diseases
/
Retroelements
/
Endogenous Retroviruses
Limits:
Animals
/
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
JVI.02299-20
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