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The Effects of Vitamin D on Immune System and Inflammatory Diseases.
Ao, Tomoka; Kikuta, Junichi; Ishii, Masaru.
  • Ao T; Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka 565-0871, Japan.
  • Kikuta J; WPI-Immunology Frontier Research Center, Department of Immunology and Cell Biology, Osaka University, Osaka 565-0871, Japan.
  • Ishii M; Laboratory of Bioimaging and Drug Discovery, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan.
Biomolecules ; 11(11)2021 11 03.
Article in English | MEDLINE | ID: covidwho-1502359
ABSTRACT
Immune cells, including dendritic cells, macrophages, and T and B cells, express the vitamin D receptor and 1α-hydroxylase. In vitro studies have shown that 1,25-dihydroxyvitamin D, the active form of vitamin D, has an anti-inflammatory effect. Recent epidemiological evidence has indicated a significant association between vitamin D deficiency and an increased incidence, or aggravation, of infectious diseases and inflammatory autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. However, the impact of vitamin D on treatment and prevention, particularly in infectious diseases such as the 2019 coronavirus disease (COVID-19), remains controversial. Here, we review recent evidence associated with the relationship between vitamin D and inflammatory diseases and describe the underlying immunomodulatory effect of vitamin D.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / COVID-19 / COVID-19 Drug Treatment / Immune System / Inflammation Type of study: Experimental Studies / Observational study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Biom11111624

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / COVID-19 / COVID-19 Drug Treatment / Immune System / Inflammation Type of study: Experimental Studies / Observational study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Biom11111624