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The Role of Endothelium in COVID-19.
Ionescu, Mihaela; Stoian, Anca Pantea; Rizzo, Manfredi; Serban, Dragos; Nuzzo, Domenico; Mazilu, Laura; Suceveanu, Andra Iulia; Dascalu, Ana Maria; Parepa, Irinel Raluca.
  • Ionescu M; Cardiology Department, Faculty of Medicine, Ovidius University of Constanta, 900527 Constanta, Romania.
  • Stoian AP; Diabetes, Nutrition, and Metabolic Diseases Department, Faculty of Medicine, Carol Davila University, 050474 Bucharest, Romania.
  • Rizzo M; Diabetes, Nutrition, and Metabolic Diseases Department, Faculty of Medicine, Carol Davila University, 050474 Bucharest, Romania.
  • Serban D; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, Italy.
  • Nuzzo D; Forth Surgery Department, Emergency University Hospital Bucharest and Faculty of Medicine, Carol Davila University, 050474 Bucharest, Romania.
  • Mazilu L; Italian National Research Council, Institute for Research and Biomedical Innovation (CNR-IRIB), 90100 Palermo, Italy.
  • Suceveanu AI; Oncology Department, Faculty of Medicine, Ovidius University of Constanta, 900527 Constanta, Romania.
  • Dascalu AM; Internal Medicine Department, Faculty of Medicine, Ovidius University of Constanta, 900527 Constanta, Romania.
  • Parepa IR; Department of Ophthalmology, Emergency University Hospital Bucharest and Faculty of Medicine, Carol Davila University, 050474 Bucharest, Romania.
Int J Mol Sci ; 22(21)2021 Nov 03.
Article in English | MEDLINE | ID: covidwho-1502439
ABSTRACT
The 2019 novel coronavirus, known as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19), is causing a global pandemic. The virus primarily affects the upper and lower respiratory tracts and raises the risk of a variety of non-pulmonary consequences, the most severe and possibly fatal of which are cardiovascular problems. Data show that almost one-third of the patients with a moderate or severe form of COVID-19 had preexisting cardiovascular comorbidities such as diabetes mellitus, obesity, hypertension, heart failure, or coronary artery disease. SARS-CoV2 causes hyper inflammation, hypoxia, apoptosis, and a renin-angiotensin system imbalance in a variety of cell types, primarily endothelial cells. Profound endothelial dysfunction associated with COVID-19 can be the cause of impaired organ perfusion that may generate acute myocardial injury, renal failure, and a procoagulant state resulting in thromboembolic events. We discuss the most recent results on the involvement of endothelial dysfunction in the pathogenesis of COVID-19 in patients with cardiometabolic diseases in this review. We also provide insights on treatments that may reduce the severity of this viral infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelial Cells / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms222111920

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelial Cells / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms222111920