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Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2.
Tang, Qilong; Owens, Raymond J; Naismith, James H.
  • Tang Q; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot OX11 0FA, UK.
  • Owens RJ; The Wellcome Centre for Human Genetics, Division of Structural Biology, University of Oxford, Headington, Oxford OX3 7BN, UK.
  • Naismith JH; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot OX11 0FA, UK.
Viruses ; 13(11)2021 11 03.
Article in English | MEDLINE | ID: covidwho-1502530
ABSTRACT
Nanobodies are 130 amino acid single-domain antibodies (VHH) derived from the unique heavy-chain-only subclass of Camelid immunogloblins. Their small molecular size, facile expression, high affinity and stability have combined to make them unique targeting reagents with numerous applications in the biomedical sciences. The first nanobody agent has now entered the clinic as a treatment against a blood disorder. The spread of the SARS-CoV-2 virus has seen the global scientific endeavour work to accelerate the development of technologies to try to defeat a pandemic that has now killed over four million people. In a remarkably short period of time, multiple studies have reported nanobodies directed against the viral Spike protein. Several agents have been tested in culture and demonstrate potent neutralisation of the virus or pseudovirus. A few agents have completed animal trials with very encouraging results showing their potential for treating infection. Here, we discuss the structural features that guide the nanobody recognition of the receptor binding domain of the Spike protein of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Protein Interaction Domains and Motifs / Antibodies, Neutralizing / Single-Domain Antibodies / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / Antibodies, Viral Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13112214

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Protein Interaction Domains and Motifs / Antibodies, Neutralizing / Single-Domain Antibodies / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / Antibodies, Viral Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13112214