Catastrophic Presentation of COVID-19 with Solitary Large Denovo Tumefactive Demyelination.
Neurol India
; 69(5): 1424-1426, 2021.
Article
in English
| MEDLINE | ID: covidwho-1502579
ABSTRACT
BACKGROUND:
The ongoing Coronavirus disease-19 (COVID-19) pandemic has revealed a plethora of extrapulmonary manifestations including neurological presentations. To date, nervous system demyelination has been relatively infrequently reported in this setting. Also, while most data point toward immune activation as a causative process, few studies propound a direct effect. CASE DESCRIPTION A 35-year-old man presented with severe new-onset headache, hemiparesis, and focal seizures culminating in deeply altered sensorium. Radiological evaluation showed a large expansile demyelinating lesion in the right cerebral hemisphere. Nasopharyngeal swab COVID reverse transcription-polymerase chain reaction (RT-PCR) was positive. After initial non-response to steroids, the patient responded well to plasma exchange leading to complete recovery.CONCLUSIONS:
This report highlights a case of active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presenting with tumefactive demyelination and subsequent response to therapy. It is important to recognize atypical presentations at this juncture as it may be crucial for planning treatment strategies.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Demyelinating Diseases
/
COVID-19
Type of study:
Case report
/
Experimental Studies
/
Prognostic study
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Neurol India
Year:
2021
Document Type:
Article
Affiliation country:
0028-3886.329572
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