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Increased complications of COVID-19 in people with cardiovascular disease: Role of the renin-angiotensin-aldosterone system (RAAS) dysregulation.
Augustine, Robin; S, Abhilash; Nayeem, Ajisha; Salam, Shaheen Abdul; Augustine, Priya; Dan, Pan; Maureira, Pablo; Mraiche, Fatima; Gentile, Carmine; Hansbro, Philip M; McClements, Lana; Hasan, Anwarul.
  • Augustine R; Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, 2713, Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713, Doha, Qatar. Electronic address: robin.augustine@qu.edu.qa.
  • S A; Department of Microbiology, Majlis Arts and Science College, Puramannur, Malappuram, Kerala, 676552, India.
  • Nayeem A; Department of Biotechnology, St. Mary's College, Thrissur, 680020, Kerala, India.
  • Salam SA; Department of Biosciences, MES College Marampally, Aluva, Ernakulam, 683107, Kerala, India.
  • Augustine P; Department of Zoology, Kongunadu Arts and Science College, Coimbatore, Tamil Nadu, 641029, India.
  • Dan P; Department of Cardiovascular and Transplantation Surgery, Regional Central Hospital of Nancy, Lorraine University, France; Department of Thoracic and Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
  • Maureira P; Department of Cardiovascular and Transplantation Surgery, Regional Central Hospital of Nancy, Lorraine University, France.
  • Mraiche F; College of Pharmacy, QU-Health, Qatar University, PO Box 2713, Doha, Qatar.
  • Gentile C; School of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, NSW, Australia; School of Medicine, Faculty of Medicine and Health, University of Sydney, NSW, Australia; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Hansbro PM; Centre for Inflammation, Centenary Institute and University of Technology Sydney, NSW, Australia; School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW, Australia.
  • McClements L; School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW, Australia.
  • Hasan A; Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, 2713, Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713, Doha, Qatar. Electronic address: ahasan@qu.edu.qa.
Chem Biol Interact ; 351: 109738, 2022 Jan 05.
Article in English | MEDLINE | ID: covidwho-1503574
ABSTRACT
The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19), has had a dramatic negative impact on public health and economies worldwide. Recent studies on COVID-19 complications and mortality rates suggest that there is a higher prevalence in cardiovascular diseases (CVD) patients. Past investigations on the associations between pre-existing CVDs and susceptibility to coronavirus infections including SARS-CoV and the Middle East Respiratory Syndrome coronavirus (MERS-CoV), have demonstrated similar results. However, the underlying mechanisms are poorly understood. This has impeded adequate risk stratification and treatment strategies for CVD patients with SARS-CoV-2 infections. Generally, dysregulation of the expression of angiotensin-converting enzyme (ACE) and the counter regulator, angiotensin-converting enzyme 2 (ACE2) is a hallmark of cardiovascular risk and CVD. ACE2 is the main host receptor for SARS-CoV-2. Although further studies are required, dysfunction of ACE2 after virus binding and dysregulation of the renin-angiotensin-aldosterone system (RAAS) signaling may worsen the outcomes of people affected by COVID-19 and with preexisting CVD. Here, we review the current knowledge and outline the gaps related to the relationship between CVD and COVID-19 with a focus on the RAAS. Improved understanding of the mechanisms regulating viral entry and the role of RAAS may direct future research with the potential to improve the prevention and management of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renin-Angiotensin System / Cardiovascular Diseases / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Chem Biol Interact Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renin-Angiotensin System / Cardiovascular Diseases / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Chem Biol Interact Year: 2022 Document Type: Article