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Human IgM and IgG Responses to an Inactivated SARS-CoV-2 Vaccine.
Banga Ndzouboukou, Jo-Lewis; Zhang, Yan-di; Lei, Qing; Lin, Xiao-Song; Yao, Zong-Jie; Fu, Hui; Yuan, Le-Yong; Fan, Xiong-Lin.
  • Banga Ndzouboukou JL; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Zhang YD; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Lei Q; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Lin XS; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Yao ZJ; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Fu H; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Yuan LY; Department of Clinical Laboratory, Southern University of Science and Technology Hospital, Shenzhen, 518055, China. leyongyuan@whu.edu.cn.
  • Fan XL; Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, 442000, China. leyongyuan@whu.edu.cn.
Curr Med Sci ; 41(6): 1081-1086, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1503610
ABSTRACT

OBJECTIVE:

The ongoing COVID-19 pandemic warrants accelerated efforts to test vaccine candidates. To explore the influencing factors on vaccine-induced effects, antibody responses to an inactivated SARS-CoV-2 vaccine in healthy individuals who were not previously infected by COVID-19 were assessed.

METHODS:

All subjects aged 18-60 years who did not have SARS-CoV-2 infection at the time of screening from June 19, 2021, to July 02, 2021, were approached for inclusion. All participants received two doses of inactivated SARS-CoV-2 vaccine. Serum IgM and IgG antibodies were detected using a commercial kit after the second dose of vaccination. A positive result was defined as 10 AU/mL or more and a negative result as less than 10 AU/mL. This retrospective study included 97 infection-naïve individuals (mean age 35.6 years; 37.1% male, 62.9% female).

RESULTS:

The seropositive rates of IgM and IgG antibody responses elicited after the second dose of inactivated SARS-CoV-2 vaccine were 3.1% and 74.2%, respectively. IgG antibody levels were significantly higher than IgM levels (P<0.0001). Sex had no effect on IgM and IgG antibody response after the second dose. The mean anti-IgG level in older persons (⩾42 years) was significantly lower than that of younger recipients. There was a significantly lower antibody level at > 42 days compared to that at 0-20 days (P<0.05) and 21-31 days (P<0.05) after the second dose.

CONCLUSION:

IgG antibody response could be induced by inactivated SARS-CoV-2 vaccine in healthy individuals (>18 years), which can be influenced by age and detection time after the second dose of vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines, Inactivated / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Observational study Topics: Vaccines Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Curr Med Sci Year: 2021 Document Type: Article Affiliation country: S11596-021-2461-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines, Inactivated / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Observational study Topics: Vaccines Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Curr Med Sci Year: 2021 Document Type: Article Affiliation country: S11596-021-2461-8