Current treatment strategies for COVID19 (Review).
Mol Med Rep
; 24(6)2021 12.
Article
in English
| MEDLINE | ID: covidwho-1504040
ABSTRACT
The spread of the novel severe acute respiratory syndrome coronavirus 2 (SARSCoV2) emerged suddenly at the end of 2019 and the disease came to be known as coronavirus disease 2019 (COVID19). To date, there is no specific therapy established to treat COVID19. Identifying effective treatments is urgently required to treat patients and stop the transmission of SARSCoV2 in humans. For the present review, >100 publications on therapeutic agents for COVID19, including in vitro and in vivo animal studies, case reports, retrospective analyses and metaanalyses were retrieved from PubMed and analyzed, and promising therapeutic agents that may be used to combat SARSCoV2 infection were highlighted. Since the outbreak of COVID19, different drugs have been repurposed for its treatment. Existing drugs, including chloroquine (CQ), its derivative hydroxychloroquine (HCQ), remdesivir and nucleoside analogues, monoclonal antibodies, convalescent plasma, Chinese herbal medicine and natural compounds for treating COVID19 evaluated in experimental and clinical studies were discussed. Although early clinical studies suggested that CQ/HCQ produces antiviral action, later research indicated certain controversy regarding their use for treating COVID19. The molecular mechanisms of these therapeutic agents against SARSCoV2 have been investigated, including inhibition of viral interactions with angiotensinconverting enzyme 2 receptors in human cells, viral RNAdependent RNA polymerase, RNA replication and the packaging of viral particles. Potent therapeutic options were reviewed and future challenges to accelerate the development of novel therapeutic agents to treat and prevent COVID19 were acknowledged.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
Topics:
Traditional medicine
Limits:
Animals
/
Humans
Language:
English
Year:
2021
Document Type:
Article
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