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SARS-CoV-2 vaccine uptake in a multi-ethnic UK healthcare workforce: A cross-sectional study.
Martin, Christopher A; Marshall, Colette; Patel, Prashanth; Goss, Charles; Jenkins, David R; Ellwood, Claire; Barton, Linda; Price, Arthur; Brunskill, Nigel J; Khunti, Kamlesh; Pareek, Manish.
  • Martin CA; Department of Respiratory Sciences, University of Leicester, Leicester, United Kingdom.
  • Marshall C; Department of Infection and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
  • Patel P; University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
  • Goss C; Department of Chemical Pathology and Metabolic Diseases, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
  • Jenkins DR; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
  • Ellwood C; Department of Occupational Health, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
  • Barton L; Department of Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
  • Price A; Department of Pharmacy, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
  • Brunskill NJ; Department of Haematology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
  • Khunti K; Department of Immunology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
  • Pareek M; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
PLoS Med ; 18(11): e1003823, 2021 11.
Article in English | MEDLINE | ID: covidwho-1504361
ABSTRACT

BACKGROUND:

Healthcare workers (HCWs) and ethnic minority groups are at increased risk of COVID-19 infection and adverse outcomes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is now available for frontline UK HCWs; however, demographic/occupational associations with vaccine uptake in this cohort are unknown. We sought to establish these associations in a large UK hospital workforce. METHODS AND

FINDINGS:

We conducted cross-sectional surveillance examining vaccine uptake amongst all staff at University Hospitals of Leicester NHS Trust. We examined proportions of vaccinated staff stratified by demographic factors, occupation, and previous COVID-19 test results (serology/PCR) and used logistic regression to identify predictors of vaccination status after adjustment for confounders. We included 19,044 HCWs; 12,278 (64.5%) had received SARS-CoV-2 vaccination. Compared to White HCWs (70.9% vaccinated), a significantly smaller proportion of ethnic minority HCWs were vaccinated (South Asian, 58.5%; Black, 36.8%; p < 0.001 for both). After adjustment for age, sex, ethnicity, deprivation, occupation, SARS-CoV-2 serology/PCR results, and COVID-19-related work absences, factors found to be negatively associated with vaccine uptake were younger age, female sex, increased deprivation, pregnancy, and belonging to any non-White ethnic group (Black adjusted odds ratio [aOR] 0.30, 95% CI 0.26-0.34, p < 0.001; South Asian aOR 0.67, 95% CI 0.62-0.72, p < 0.001). Those who had previously had confirmed COVID-19 (by PCR) were less likely to be vaccinated than those who had tested negative. Limitations include data being from a single centre, lack of data on staff vaccinated outside the hospital system, and that staff may have taken up vaccination following data extraction.

CONCLUSIONS:

Ethnic minority HCWs and those from more deprived areas as well as younger staff and female staff are less likely to take up SARS-CoV-2 vaccination. These findings have major implications for the delivery of SARS-CoV-2 vaccination programmes, in HCWs and the wider population, and should inform the national vaccination programme to prevent the disparities of the pandemic from widening.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / Health Personnel / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Prevalence study / Prognostic study / Randomized controlled trials / Reviews / Risk factors Limits: Humans Country/Region as subject: Europa Language: English Journal: PLoS Med Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pmed.1003823

Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / Health Personnel / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Prevalence study / Prognostic study / Randomized controlled trials / Reviews / Risk factors Limits: Humans Country/Region as subject: Europa Language: English Journal: PLoS Med Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pmed.1003823