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Estimating the impact of virus testing strategies on the COVID-19 case fatality rate using fixed-effects models.
Terriau, Anthony; Albertini, Julien; Montassier, Emmanuel; Poirier, Arthur; Le Bastard, Quentin.
  • Terriau A; GAINS, Le Mans University, 72000, Le Mans, France.
  • Albertini J; GATE, University of Lyon 2, 69000, Lyon, France.
  • Montassier E; MiHAR Lab, University of Nantes, 44000, Nantes, France.
  • Poirier A; Department of Emergency Medicine, Nantes University Hospital, 44000, Nantes, France.
  • Le Bastard Q; GAINS, Le Mans University, 72000, Le Mans, France.
Sci Rep ; 11(1): 21650, 2021 11 04.
Article in English | MEDLINE | ID: covidwho-1504883
ABSTRACT
The SARS-CoV2 has now spread worldwide causing over four million deaths. Testing strategies are highly variable between countries and their impact on mortality is a major issue. Retrospective multicenter study with a prospective database on all inpatients throughout mainland France. Using fixed effects models, we exploit policy discontinuities at region borders in France to estimate the effect of testing on the case fatality rate. In France, testing policies are determined at a regional level, generating exogenous variation in testing rates between departments on each side of a region border. We compared all contiguous department pairs located on the opposite sides of a region border. The increase of one percentage point in the test rate is associated with a decrease of 0.0015 percentage point in the death rate, that is, for each additional 2000 tests, we could observe three fewer deaths. Our study suggests that COVID-19 population testing could have a significant impact on the mortality rate which should be considered in decision-making. As concern grows over the current second wave of COVID-19, our findings support the implementation of large-scale screening strategies in such epidemic contexts.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Testing / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-01034-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Testing / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-01034-7