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Breakthrough COVID-19 and Casirivimab-Imdevimab Treatment during a SARS-CoV-2 B.1.617.2 (Delta) Surge
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology ; 2021.
Article in English | EuropePMC | ID: covidwho-1505319
ABSTRACT

Introduction:

The impact of vaccination and casirivimab-imdevimab monoclonal antibody treatment on the clinical outcome of COVID-19 during a period of SARS-CoV-2 Delta surge is not known. Aim and

Methods:

All patients with COVID-19 at our facilities in the US Midwest were enrolled to assess breakthrough cases among vaccinated individuals and to compare the rates of hospitalization between casirivimab-imdevimab treated versus untreated patients. The study period occurred in July 2021 during a period dominated by the Delta variant.

Results:

The majority (68.1%) of 630 COVID-19 cases occurred in unvaccinated individuals. Among 403 patients eligible for monoclonal antibody treatment, the 28-day hospitalization rate was 2.6% of 112 patients who received treatment with casirivimab-imdevimab, compared to 16.6% of 291 eligible high-risk patients who did not receive casirivimab-imdevimab (Odds Ratio [OR] 0.138, 95% confidence interval (CI) 0.0426-0.4477, p=0.001). Casirivimab-imdevimab treatment was associated with lower rates of hospitalization among the vaccinated and unvaccinated cohorts.

Conclusions:

During a SARS-CoV-2 Delta surge, breakthrough COVID-19 occurred among vaccinated persons, especially among those with multiple medical comorbidities. Casirivimab-imdevimab treatment was associated with significantly lower rates of hospitalization in vaccinated and unvaccinated persons.
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Collection: Databases of international organizations Database: EuropePMC Topics: Vaccines Language: English Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: EuropePMC Topics: Vaccines Language: English Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Year: 2021 Document Type: Article