Severe acute respiratory syndrome coronavirus 2 infection in patients with prostate cancer: A critical review.
Crit Rev Oncol Hematol
; 167: 103491, 2021 Nov.
Article
in English
| MEDLINE | ID: covidwho-1505718
ABSTRACT
Real-world data suggest a possible interplay between androgen deprivation therapy (ADT) and susceptibility to and the severity of SARS-CoV-2 infection. As ADT is the backbone of prostate cancer treatment, various authors have evaluated different patient cohorts but the evidence provided is conflicting. The aim of this review is to assess the available publications concerning the role of ADT in preventing or reducing the severity of SARS-CoV-2 infection. After a literature search we identified four full papers, five letters, and four meeting abstracts, but these used different search methods and the quality of the evidence varied. They frequently had different endpoints, did not report the status of the prostate cancer patients and evaluated heterogeneous populations. The available data do not support the view that ADT protects against SARS-CoV-2 infection. Larger and more precise studies are warranted, considering variables that affect infection outcomes as these significantly influence the reliability of the findings.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
Topics:
Long Covid
Limits:
Humans
/
Male
Language:
English
Journal:
Crit Rev Oncol Hematol
Journal subject:
Hematology
/
Neoplasms
Year:
2021
Document Type:
Article
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