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Effects of hydroxychloroquine and its metabolites in patients with connective tissue diseases.
Eryavuz Onmaz, Duygu; Tezcan, Dilek; Abusoglu, Sedat; Yilmaz, Sema; Yerlikaya, Fatma Humeyra; Onmaz, Mustafa; Abusoglu, Gulsum; Unlu, Ali.
  • Eryavuz Onmaz D; Department of Biochemistry, Faculty of Medicine, Selcuk University, Alaaddin Keykubat Campus, 42075, Konya, Turkey. duygu_eryavuz@hotmail.com.
  • Tezcan D; Division of Rheumatology, Faculty of Medicine, Selcuk University, Konya, 42130, Turkey.
  • Abusoglu S; Department of Biochemistry, Faculty of Medicine, Selcuk University, Alaaddin Keykubat Campus, 42075, Konya, Turkey.
  • Yilmaz S; Division of Rheumatology, Faculty of Medicine, Selcuk University, Konya, 42130, Turkey.
  • Yerlikaya FH; Department of Biochemistry, Faculty of Medicine, Selcuk University, Alaaddin Keykubat Campus, 42075, Konya, Turkey.
  • Onmaz M; Department of Family Medicine, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
  • Abusoglu G; Department of Medical Laboratory Techniques, Vocational School of Health, Selcuk University, Konya, Turkey.
  • Unlu A; Department of Biochemistry, Faculty of Medicine, Selcuk University, Alaaddin Keykubat Campus, 42075, Konya, Turkey.
Inflammopharmacology ; 29(6): 1795-1805, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1505910
ABSTRACT
Hydroxychloroquine has attracted attention in the treatment of COVID-19. Many conflicting findings have been reported regarding the efficacy and safety of this drug, which has been used safely in the rheumatological diseases for years. However, these studies lacked measurement methods that allow accurate assessment of hydroxychloroquine and its metabolite levels. The aim of this study was to measure hydroxychloroquine and its metabolite levels in whole blood samples of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjogren's syndrome (SS) and scleroderma (Scl) by a robust, simple and accurate validated tandem mass spectrometric method, and to investigate the relationship between these levels with drug-related adverse effects and disease activity scores. The validated LC-MS/MS method was applied to measure blood hydroxychloroquine and its metabolite levels of patients with RA, SLE, SS, Scl. Various haematological and biochemical parameters were measured with Beckman-Coulter AU 5800 and Beckman Coulter LH 780 analyzers, respectively. QTc intervals were calculated with Bazett's formula, and the patients were followed up by clinicians in terms of clinical findings and adverse effects. Hydroxychloroquine levels of patients were similar to previous studies. There was a negative correlation between disease activity scores and hydroxychloroquine levels, while the highest correlation was between QTc interval, creatinine and GFR levels with desethylchloroquine. Bidetylchloroquine had the highest correlation with RBC count and liver function tests. Our findings showed that hydroxychloroquine and its metabolite levels were associated with disease activity scores, renal, hepatic function, QTc prolongation, and hematological parameters.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Connective Tissue Diseases / COVID-19 / Hydroxychloroquine / Antimalarials Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Inflammopharmacology Journal subject: Pharmacology / Drug Therapy Year: 2021 Document Type: Article Affiliation country: S10787-021-00887-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Connective Tissue Diseases / COVID-19 / Hydroxychloroquine / Antimalarials Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Inflammopharmacology Journal subject: Pharmacology / Drug Therapy Year: 2021 Document Type: Article Affiliation country: S10787-021-00887-8