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COCARDE Study-Cardiac Imaging Phenotype in Patients With COVID-19: Protocol for a Prospective Observational Study.
Lairez, Olivier; Blanchard, Virginie; Balardy, Laurent; Vardon-Bounes, Fanny; Cazalbou, Stéphanie; Ruiz, Stéphanie; Collot, Samia; Houard, Valérie; Rolland, Yves; Conil, Jean-Marie; Minville, Vincent.
  • Lairez O; Department of Cardiology, Rangueil University Hospital, Toulouse, France.
  • Blanchard V; Department of Cardiology, Rangueil University Hospital, Toulouse, France.
  • Balardy L; Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital, Toulouse, France.
  • Vardon-Bounes F; Department of Anesthesiology and Intensive Care, Toulouse University Hospital, Toulouse, France.
  • Cazalbou S; Department of Cardiology, Rangueil University Hospital, Toulouse, France.
  • Ruiz S; Department of Anesthesiology and Intensive Care, Toulouse University Hospital, Toulouse, France.
  • Collot S; Department of Radiology, Rangueil University Hospital, Toulouse, France.
  • Houard V; Department of Cardiology, Rangueil University Hospital, Toulouse, France.
  • Rolland Y; Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital, Toulouse, France.
  • Conil JM; Department of Anesthesiology and Intensive Care, Toulouse University Hospital, Toulouse, France.
  • Minville V; Department of Anesthesiology and Intensive Care, Toulouse University Hospital, Toulouse, France.
JMIR Res Protoc ; 11(1): e24931, 2022 Jan 06.
Article in English | MEDLINE | ID: covidwho-1605998
ABSTRACT

BACKGROUND:

The effects of SARS-CoV-2 (COVID-19) on the myocardium and their role in the clinical course of infected patients are still unknown. The severity of SARS-CoV-2 is driven by hyperinflammation, and the effects of SARS-CoV-2 on the myocardium may be significant. This study proposes to use bedside observations and biomarkers to characterize the association of COVID-19 with myocardial injury.

OBJECTIVE:

The aim of the study is to describe the myocardial function and its evolution over time in patients infected with SARS-CoV-2 and to investigate the link between inflammation and cardiac injury.

METHODS:

This prospective, monocentric, observational study enrolled 150 patients with suspected or confirmed SARS-CoV-2 infection at Toulouse University Hospital, Toulouse, France. Patients admitted to the intensive care unit (ICU), regular cardiologic ward, and geriatric ward of our tertiary university hospital were included during the pandemic period. Blood sampling, electrocardiography, echocardiography, and morphometric and demographic data were prospectively collected.

RESULTS:

A total of 100 patients were included. The final enrolment day was March 31, 2020, with first report of results at the end of the first quarter of 2021. The first echocardiographic results at admission of 31 patients of the COCARDE-ICU substudy population show that biological myocardial injury in COVID-19 has low functional impact on left ventricular systolic function.

CONCLUSIONS:

A better understanding of the effects of COVID-19 on myocardial function and its link with inflammation would improve patient follow-up and care. TRIAL REGISTRATION Clinicaltrials.gov NCT04358952; https//clinicaltrials.gov/ct2/show/NCT04358952. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID) DERR1-10.2196/24931.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: JMIR Res Protoc Year: 2022 Document Type: Article Affiliation country: 24931

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: JMIR Res Protoc Year: 2022 Document Type: Article Affiliation country: 24931