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Rapid differential diagnosis of the B.1.617.2 (delta) variant of SARS-CoV-2 using an automated Cas12a-microfluidic system.
Li, Pintao; Zhang, Jin; Lin, Qiuyuan; Kong, Jilie; Fang, Xueen.
  • Li P; Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P. R. China. fxech@fudan.edu.cn.
  • Zhang J; Qingdao International Travel Healthcare Center, Qingdao Customs, Qingdao 266071, P. R. China. zhjoohyn@hotmail.com.
  • Lin Q; Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P. R. China. fxech@fudan.edu.cn.
  • Kong J; Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P. R. China. fxech@fudan.edu.cn.
  • Fang X; Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P. R. China. fxech@fudan.edu.cn.
Chem Commun (Camb) ; 57(92): 12270-12272, 2021 Nov 19.
Article in English | MEDLINE | ID: covidwho-1506302
ABSTRACT
An automated Cas12a-microfluidic system was constructed to distinguish the B.1.617.2 (delta) variant of SARS-CoV-2 from the wild-type virus rapidly and was validated using 30 clinical samples, showing 100% consistency with next-generation sequencing. It will be a potential tool for the rapid differential diagnosis of the delta variant of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Microfluidics / CRISPR-Cas Systems / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Microfluidics / CRISPR-Cas Systems / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2021 Document Type: Article